NCT07650149Recruiting
Genetic, Microbiological and Behavioral Factors in Obesity
OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity. 200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 10 Jun 2026
- Start date
- 23 May 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- Jan Kochanowski University
- Diseases
- Obesity
- NCT number
- NCT07650149
What you commit to
- Study type: Observational
- Planned participants: 200
- From 23 May 2026 to the primary completion date, 31 May 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking immunosuppressive medications, steroids, NSAIDs, antibiotics (within 2 weeks prior to sample collection),
Other illness
- Type 1 or type 2 diabetes
- Cancer
- Heart failure
- Autoimmune and inflammatory diseases, acute infectious diseases, AIDS, tuberculosis
- Mental illness
- Alcohol dependence syndrome
- Post-myocardial infarction or stroke
Other
- Contraindications to tirzepatide use:
- Pregnancy or breastfeeding
- Expected lack of patient compliance
- Liver cirrhosis
Who the study is looking for
- Age 18-65 years
- Consent to participate in the study and providing informed written consent
- Overweight or obese with a BMI \>27
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Waga Zmiany Coordinator of this site? Confirm its status | Krakow | Poland | Recruiting |
| Luxmed sp zoo Coordinator of this site? Confirm its status | Warsaw | Poland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.