NCT07650682Recruiting
Mathematical Modeling of Blood Sugar and Hormone Responses in Insulin-Dependent Type 2 Diabetes
Mathematical Modeling of Type 2 Diabetes Mellitus
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
This observational study aims to collect detailed metabolic and physiologic data from adults with insulin-dependent type 2 diabetes mellitus following consumption of a mixed meal tolerance test. Participants will undergo frequent blood sampling over a 4-hour period after consuming a standardized liquid mixed meal to measure glucose, insulin, glucagon, C-peptide, and triglyceride responses. Participants will also use continuous glucose monitoring and wearable physical activity tracking devices during free-living conditions. The purpose of this study is to develop mathematical models and digital representations ("digital twins") of people with type 2 diabetes mellitus. These models may help researchers better understand metabolic responses to meals, physical activity, and diabetes treatments, and may support future development of personalized diabetes technologies and therapies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 25 (estimated)
- First submitted
- 29 May 2026
- Start date
- 20 May 2026
- Primary completion date
- 20 Oct 2026
- Lead sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
- Diseases
- Type 1 diabetes, Type 2 diabetes
- NCT number
- NCT07650682
What you commit to
- Study type: Observational
- Planned participants: 25
- From 20 May 2026 to the primary completion date, 20 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI.
- Unstable weight: gained or lost weight +/- 5 kg (11 lbs) in previous 2 months
Other illness
- Men and women with known or suspected intolerance, allergies, or hypersensitivity to study foods
- History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional
Lab values
- Men and women with low hemoglobin (Hgb) levels below 9.5 g/dL at the screening visit, indicating anemia
Other
- Men and women with blood pressure \>160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit
- Women who are pregnant or planning to become pregnant during the study
- Vegan or other extreme dietary regimens (e.g., Atkins diet, etc.) as judged by the investigator
- Donated blood within the last 3 months
- Unusual working hours i.e., working overnight (e.g. 3rd shift)
Who the study is looking for
- Men or women, 18-65 years of age
- Diagnosed with insulin-dependent type 2 diabetes mellitus HbA1c ≥ 6.5% at screening
- Current insulin therapy for ≥ 6 months prior to screening
- Nonsmokers (past smokers can be allowed if they have abstained for a minimum of 12 months)
- Judged to be in good health based on medical history (i.e., no clinical evidence of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease)
- Able to provide informed consent
- Able to comply with and perform the procedures requested by the protocol (including dietary restrictions, consumption of study foods, records of food diary, sample collection procedures, and study visit schedule)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Illinois Institute of Technology Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.