NCT07652073Not yet recruitingPhase 2
A Study of DAT-2645 in Patients With BRCA1/2 Mutations or HRD-Positive Ovarian Cancer
A Phase II Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of DAT-2645 in Patients With BRCA1/2 Deleterious Mutations or HRD-Positive Advanced/Metastatic Ovarian Cancer
Source: ClinicalTrials.gov · Last updated 25 Jun 2026
Brief summary (registry, in English)
This is a Phase II, multicenter, single-arm dose expansion trial planned to enroll up to 30 subjects with advanced or metastatic ovarian cancer. The Objective is to conduct a preliminary evaluation of the efficacy, the safety, tolerability and PK profile of DAT-2645
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 11 Jun 2026
- Start date
- 15 Jun 2026
- Primary completion date
- 30 Nov 2027
- Lead sponsor
- Danatlas Pharmaceuticals Co., Ltd
- Diseases
- Ovarian cancer
- NCT number
- NCT07652073
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 30
- From 15 Jun 2026 to the primary completion date, 30 Nov 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received small-molecule chemotherapy or targeted therapy within 2 weeks or 5 half-lives prior to the first dose
- Received treatment with an anticancer biological therapy within 4 weeks prior to the first dose
- Underwent major surgery within 4 weeks prior to the first dose
- Has previously received treatment with a PARG inhibitor
- Inadequate response to previous PARP inhibitor maintenance therapy
- Adverse reactions from prior anticancer therapy have not yet resolved to a grade ≤1
Other illness
- Patients with clinically significant cardiovascular or cerebrovascular diseases
- Uncontrolled active infections requiring intravenous antibiotics or hospitalization
Other
- With central nervous system metastases
Who the study is looking for
- sign a written informed consent form
- At least 18 years of age (inclusive)
- Epithelial ovarian cancer confirmed by histopathology or cytopathology
- BRCA1/2 mutation or HRD-positive status
- Patients who have failed standard treatment or are unable to tolerate standard treatment
- Patients must have received no more than five prior treatment lines
- At least one measurable lesion
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
- Bone marrow reserve and organ function must meet the requirements
- Negative result on a blood pregnancy test for a woman of childbearing age
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| - Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.