NCT07652216Active, not recruiting
Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, Advanced Platelet-Rich fibrin (A-PRF), and A-PRF combined with Autogenous Dentin Demineralized Matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 35 (actual)
- First submitted
- 11 Jun 2026
- Start date
- 4 Apr 2024
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Jagiellonian University
- NCT number
- NCT07652216
What you commit to
- Study type: Interventional
- Participants enrolled: 35
- From 4 Apr 2024 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Immunosuppressive therapy
- Use of medications affecting bone metabolism
Other illness
- Acute local infection at the surgical site
- Systemic diseases affecting bone healing or tissue regeneration
- History of radiotherapy in the head and neck region
Lab values
- Hematological disorders affecting platelet function, coagulation, or fibrin formation (including thrombocytopenia, coagulopathies, or anticoagulant therapy).
Other
- Pregnancy or breastfeeding
- Heavy smoking
- Inability to comply with follow-up visits or postoperative recommendations
Who the study is looking for
- Patients diagnosed with dentigerous cysts associated with impacted mandibular third molars
- Indication for surgical enucleation and tooth extraction
- Ability to provide informed consent
- Availability for postoperative follow-up examinations and CBCT assessment
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Oral Surgery, Institute of Dentistry, Jagiellonian University Medical College Coordinator of this site? Confirm its status | Krakow | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.