NCT07652333Recruiting
The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication
The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication: A Pilot Study
Source: ClinicalTrials.gov · Last updated 24 Jun 2026
Brief summary (registry, in English)
The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift. •The duration of this study is 3 months. This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 11 Jan 2026
- Start date
- May 2026
- Primary completion date
- Apr 2027
- Lead sponsor
- University of Pittsburgh
- Diseases
- Obesity
- NCT number
- NCT07652333
What you commit to
- Study type: Interventional
- Planned participants: 40
- From May 2026 to the primary completion date, Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Struggle with alcohol or other substance abuse (heavy drinking (≥4 drinks/day or ≥8 drinks/week for women; ≥5 drinks/day or ≥15 drinks/week for men), or who score ≥3 on the Drug Abuse Screening Test (DAST-10))
- Participation in any other concurrent interventional clinical trial
Other illness
- A serious heart condition, such as unstable heart disease or heart failure, irregular heartbeats that are not well controlled, severe narrowing of the heart valves, or any recent inflammation of the heart or its lining
- Cancer requiring treatment in the past 5 years
- Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome type 2 (MEN2)
- Hepatic disease or cirrhosis
- Diabetes (Type 1 or 2)
- Major risk factors for coronary heart disease such as uncontrolled high blood pressure (≥160 mm Hg systolic or ≥100 mm Hg diastolic)
- Any other medical condition that is life-threatening, can interfere with or be aggravated by the exercise training
- History of eating disorders or weight-loss surgery, unstable weight (±5% change in past 6 months), or use of obesity medication (e.g., such as Wegovy, Ozempic, Saxenda, Zepbound, Mounjaro) in the last 3 months
- History of major depression or other severe psychiatric disorders (e.g., who answer "yes" to question 9 on PHQ-9 in the Psych\_QoL\_Sleep questionnaires.)
Other
- Hypothyroidism/hyperthyroidism
- Gastroparesis
- Chronic/idiopathic acute pancreatitis
- Problems with your muscles or bones that limit your ability to exercise
- Plans to be away ≥2 weeks in the next 3 months
- Inability to give informed consent
- Pregnant or plan to become pregnant during study
Who the study is looking for
- Initiating GLP-1 RAs prescribed by physician or advanced practice practitioner and willing to withhold the start of the drug until baseline assessment completed
- Non-Smoker
- ≥18 years old
- Obese: Body Mass Index 30-45 kg/m² or BMI ≥27 + ≥1 weight related comorbidity; either hypertension or sleep apnea confirmed by participant self-report
- Inactive: not meeting the current US exercise guidelines over the past 6 months
- Capable of performing the required exercise training
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Physical Activity Research Center, University of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.