NCT07652580Recruiting
Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma
Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma Across the Military Healthcare System
Source: ClinicalTrials.gov · Last updated 3 Sept 2026
Brief summary (registry, in English)
The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 300 (estimated)
- First submitted
- 11 Jun 2026
- Start date
- 1 May 2025
- Primary completion date
- 1 May 2028
- Lead sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Diseases
- Childhood cancers
- NCT number
- NCT07652580
What you commit to
- Study type: Observational
- Planned participants: 300
- From 1 May 2025 to the primary completion date, 1 May 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has any condition that, in the opinion of the Principal Investigator, contraindicates participation in this study. Examples of situation that may contraindicate participation include but are not limited to a) some cases of cerebral vascular accidents where an individual no longer has the capacity to make their own medical decisions and a conservator or responsible family member is not available and b) an individual has active suicidal ideation and is a danger to themselves at the time of enrollment.
Other
- Does not have access to health care and primary care clinician.
- Actively undergoing induction treatment for NHL.
Who the study is looking for
- Age 4 years old and older with a clinical diagnosis of B-cell NHL.
- Must be willing to undergo phlebotomy and/or skin punch biopsy.
- Must be willing to undergo whole genome sequencing, which includes return of primary and secondary findings.
Age in the registry: 4 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Walter Reed National Military Medical Center Coordinator of this site? Confirm its status | Bethesda | United States | Recruiting |
| Uniformed Services University of the Health Sciences Coordinator of this site? Confirm its status | Bethesda | United States | Active, not recruiting |
| Naval Medical Center - Portsmouth Coordinator of this site? Confirm its status | Portsmouth | United States | Active, not recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.