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NCT07652658RecruitingPhase 2

A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.

A Phase IIb Study to Evaluate the Efficacy, Safety, and Tolerability of AZD8965 in Participants With Idiopathic Pulmonary Fibrosis (IPF) (ARGiNAUT)

Source: ClinicalTrials.gov · Last updated 29 Oct 2026

Brief summary (registry, in English)

This Phase IIb study aims to evaluate the efficacy, safety, and tolerability of 3 doses of AZD8965 treatment compared to placebo in participants with IPF, including those on antifibrotic therapy (nintedanib, pirfenidone, nerandomilast), either alone or in combination, or in those not on antifibrotic therapy.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
359 (estimated)
First submitted
5 May 2026
Start date
11 Jun 2026
Primary completion date
18 Sept 2028
Lead sponsor
AstraZeneca
NCT number
NCT07652658

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 359
  • From 11 Jun 2026 to the primary completion date, 18 Sept 2028
  • 175 sites in 23 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Lower respiratory tract infection requiring treatment
  • Acute coronary syndrome/acute myocardial infarction, unstable angina ± coronary intervention with Percutaneous Coronary Intervention, or Coronary Artery Bypass Grafting
  • Heart failure
  • History of organ transplantation or is likely to receive lung transplantation

Other

  • ILD other than IPF
  • The extent of emphysema is greater than the extent of fibrotic changes on chest HRCT scan
  • Acute exacerbation of IPF

Who the study is looking for

  • Age ≥ 40 years
  • IPF diagnosis
  • Participants with IPF receiving locally approved antifibrotic therapies at a stable dose, or participants with IPF not receiving local standard of care
  • FVC ≥ 45% predicted of normal
  • DLCO corrected for hemoglobin ≥ 25% predicted of normal

Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (175)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
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AlberdiArgentinaNot yet recruiting
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Buenos AiresArgentinaNot yet recruiting
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Ciudad de Buenos AiresArgentinaNot yet recruiting
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FloridaArgentinaNot yet recruiting
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RosarioArgentinaWithdrawn
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San FernandoArgentinaNot yet recruiting
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CamperdownAustraliaNot yet recruiting
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Port MacquarieAustraliaRecruiting
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WollongongAustraliaRecruiting
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HaskovoBulgariaWithdrawn
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PlovdivBulgariaNot yet recruiting
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RousseBulgariaRecruiting
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SofiaBulgariaNot yet recruiting
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AjaxCanadaRecruiting
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BurlingtonCanadaRecruiting
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KingstonCanadaRecruiting
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North YorkCanadaRecruiting
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Saint-Charles-BorroméeCanadaRecruiting
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SherbrookeCanadaRecruiting
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Sherwood ParkCanadaNot yet recruiting
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VancouverCanadaNot yet recruiting
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ProvidenciaChileRecruiting
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SantiagoChileRecruiting
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TalcaChileRecruiting
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Viña del MarChileRecruiting
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BeijingChinaRecruiting
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ChangchunChinaRecruiting
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ChangshaChinaNot yet recruiting
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ChengduChinaRecruiting
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GuangzhouChinaRecruiting
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LanzhouChinaNot yet recruiting
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NanchangChinaNot yet recruiting
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NanjingChinaRecruiting
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ShanghaiChinaRecruiting
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ShenyangChinaWithdrawn
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WuhanChinaRecruiting
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XuzhouChinaRecruiting
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ZhengzhouChinaNot yet recruiting
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BonnGermanyRecruiting
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CoswigGermanyNot yet recruiting
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EssenGermanyRecruiting
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Freiburg im BreisgauGermanyRecruiting
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FuldaGermanyNot yet recruiting
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GiessenGermanyRecruiting
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HamburgGermanyNot yet recruiting
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HanoverGermanyRecruiting
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HeidelbergGermanyWithdrawn
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HemerGermanyRecruiting
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KonstanzGermanyWithdrawn
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LeipzigGermanyNot yet recruiting
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LübeckGermanyNot yet recruiting
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MarburgGermanyRecruiting
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MunichGermanyRecruiting
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StuttgartGermanyRecruiting
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WittenGermanyWithdrawn
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Wuppertal-BarmenGermanyRecruiting
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AarhusDenmarkRecruiting
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CopenhagenDenmarkNot yet recruiting
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HellerupDenmarkRecruiting
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Odense CDenmarkRecruiting
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BarcelonaSpainNot yet recruiting
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L'Hospitalet de LlobregatSpainNot yet recruiting
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MadridSpainNot yet recruiting
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MálagaSpainRecruiting
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ValenciaSpainRecruiting
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AngersFranceNot yet recruiting
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BrestFranceRecruiting
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BronFranceRecruiting
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MontpellierFranceNot yet recruiting
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NiceFranceRecruiting
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ParisFranceNot yet recruiting
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RennesFranceNot yet recruiting
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ToursFranceRecruiting
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BristolUnited KingdomRecruiting
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CottinghamUnited KingdomRecruiting
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EdinburghUnited KingdomRecruiting
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ExeterUnited KingdomRecruiting
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LiverpoolUnited KingdomRecruiting
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LondonUnited KingdomRecruiting
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AthensGreeceNot yet recruiting
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HeraklionGreeceRecruiting
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IoanninaGreeceRecruiting
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PátraiGreeceNot yet recruiting
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ThessalonikiGreeceRecruiting
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BudapestHungaryNot yet recruiting
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DebrecenHungaryNot yet recruiting
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TörökbálintHungaryRecruiting
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AshkelonIsraelRecruiting
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JerusalemIsraelRecruiting
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Kfar SabaIsraelRecruiting
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Petah TikvaIsraelRecruiting
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RehovotIsraelRecruiting
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FoggiaItalyRecruiting
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ForlìItalyNot yet recruiting
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ModenaItalyNot yet recruiting
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MonzaItalyNot yet recruiting
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PaviaItalyRecruiting
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RozzanoItalyRecruiting
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SienaItalyRecruiting
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TorinoItalyNot yet recruiting
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FukuokaJapanRecruiting
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Hachioji-shiJapanRecruiting
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HamamatsuJapanNot yet recruiting
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HiroshimaJapanRecruiting
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Kakogawa-shiJapanRecruiting
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Kumagaya-shiJapanRecruiting
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KumamotoJapanNot yet recruiting
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Matsusaka-shiJapanRecruiting
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SakaishiJapanNot yet recruiting
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SendaiJapanNot yet recruiting
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Seto-shiJapanNot yet recruiting
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Shimotsuke-shiJapanNot yet recruiting
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Shinjuku-kuJapanRecruiting
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YokohamaJapanRecruiting
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Seongnam-siSouth KoreaRecruiting
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SeoulSouth KoreaRecruiting
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Benito JuárezMexicoNot yet recruiting
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Chihuahua CityMexicoNot yet recruiting
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CoyocanMexicoNot yet recruiting
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LeónMexicoNot yet recruiting
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MéridaMexicoNot yet recruiting
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MonterreyMexicoNot yet recruiting
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Oaxaca CityMexicoNot yet recruiting
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PachucaMexicoNot yet recruiting
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AmsterdamNetherlandsNot yet recruiting
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HeerlenNetherlandsRecruiting
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NieuwegeinNetherlandsRecruiting
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BialystokPolandRecruiting
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KrakowPolandWithdrawn
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LodzPolandWithdrawn
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PoznanPolandNot yet recruiting
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RzeszówPolandRecruiting
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WarsawPolandRecruiting
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Kaohsiung CityTaiwanRecruiting
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TaichungTaiwanRecruiting
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TaipeiTaiwanRecruiting
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TaoyuanTaiwanRecruiting
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YunlinTaiwanRecruiting
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Ann ArborUnited StatesNot yet recruiting
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AtlantaUnited StatesRecruiting
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AuroraUnited StatesNot yet recruiting
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BaltimoreUnited StatesNot yet recruiting
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BirminghamUnited StatesNot yet recruiting
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BoiseUnited StatesRecruiting
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BostonUnited StatesNot yet recruiting
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BurlingtonUnited StatesNot yet recruiting
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ChampaignUnited StatesRecruiting
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CharlestonUnited StatesNot yet recruiting
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ChicagoUnited StatesNot yet recruiting
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CincinnatiUnited StatesNot yet recruiting
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DallasUnited StatesNot yet recruiting
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DenverUnited StatesRecruiting
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DetroitUnited StatesNot yet recruiting
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El PasoUnited StatesRecruiting
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Fountain HillUnited StatesRecruiting
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GreensboroUnited StatesNot yet recruiting
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HoustonUnited StatesNot yet recruiting
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Kansas CityUnited StatesNot yet recruiting
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LexingtonUnited StatesNot yet recruiting
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Loma LindaUnited StatesNot yet recruiting
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Los AngelesUnited StatesNot yet recruiting
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Newport BeachUnited StatesRecruiting
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New YorkUnited StatesNot yet recruiting
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OcalaUnited StatesWithdrawn
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Oklahoma CityUnited StatesNot yet recruiting
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PhiladelphiaUnited StatesNot yet recruiting
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PhoenixUnited StatesNot yet recruiting
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RichmondUnited StatesNot yet recruiting
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SacramentoUnited StatesNot yet recruiting
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StanfordUnited StatesNot yet recruiting
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WestonUnited StatesNot yet recruiting
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Cape TownSouth AfricaRecruiting
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DurbanSouth AfricaRecruiting
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Parktown WestSouth AfricaNot yet recruiting
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Somerset WestSouth AfricaWithdrawn

This page is information, not medical advice. Discuss any trial with your doctor.