NCT07652970Recruiting
Tele-CE in Severe Stroke
Effect of Home-based Cross-education on Lower Limb Neuroplasticity in Severe Stroke
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine the effects of home-based cross-education on lower limb neuroplasticity in severe stroke. The main questions the investigators aim to answer are: * What are the effects of home-based cross-education on lower limb neuroplasticity? * What are the effects of home-based cross-education on lower limb function? * Is home-based cross-education feasible to administer and accepted by participants? Participants will take part in ten home-based, remotely supervised sessions, during which participants will either perform unilateral skill and strength training of the unaffected lower limb (Tele-Cross Education or Tele-CE) or cognitive training and unilateral movements of the unaffected lower limb (Tele-control). Each participant will experience measures of brain and spinal activity and motor function testing before and after both sessions (Tele-CE and Tele-control). Each participant will also be asked to fill out a feedback questionnaire to assess acceptability after intervention sessions (Tele-CE and Tele-control).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- 17 Jun 2026
- Primary completion date
- Jun 2027
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Stroke
- NCT number
- NCT07652970
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 17 Jun 2026 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of anti-spasticity medications
- Previous adverse reaction to TMS
- Concussion within the prior 6 months
- Metal implants in the head or face
Other illness
- Existence of other neurological disorders
- Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease)
- Implanted cardiac pacemaker
- History of seizures or epilepsy
- Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
- Skin hypersensitivity at any sites of stimulation, including the scalp, thoracolumbar spine, and peripheral limbs
- History of contact dermatitis at any of the sites of stimulation
- History of allodynia and/or hyperalgesia
- Active skin infection
- Deep vein thrombosis
- Any other skin or scalp condition that could be aggravated by stimulation
Other
- Have brainstem or cerebellar lesions.
- Mini-Mental State Examiniation score of \<21, to ensure participants have the cognitive capacity to consent and can understand instructions both in-person and during remote supervision.
- Non-English-speaking individuals
- Bone, joint or soft tissue injury
- Unable to see the tablet and zoom screen
- Unable to move non-paretic ankle (\< 5 degrees of ankle ROM)
- Fugl-Meyer Lower Extremity sensory scale score \< 6
- TMS exclusion criteria
- Skull abnormalities or fractures
- Unexplained, recurring headaches
- Current pregnancy
- PNS exclusion criteria
- Skin lesions
- Implanted electronic, metallic, or highly conductive devices near site of stimulation that cannot be removed without permission from a health professional
Who the study is looking for
- Single, monohemispheric stroke
- Chronic stroke (\> 6 months prior)
- Severe stroke (Fugl-Meyer Lower Extremity motor scale score \< 21 or 6 Minute Walk Test distance \< 300m)
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brain Plasticity Lab Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.