NCT07653464Not yet recruitingEarly phase 1
Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity
Source: ClinicalTrials.gov · Last updated 15 Oct 2026
Brief summary (registry, in English)
Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 64 (estimated)
- First submitted
- 12 Jun 2026
- Start date
- Dec 2026
- Primary completion date
- Jun 2031
- Lead sponsor
- University of Missouri-Columbia
- Diseases
- Obesity
- NCT number
- NCT07653464
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 64
- From Dec 2026 to the primary completion date, Jun 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of pharmacological therapy for weight loss
- Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
- Non-MRI compatible metal implants
Other illness
- Diabetes or polycystic ovarian syndrome
- Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
- Nerve/neurologic disease
- Uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>100 mmHg)
- Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
Other
- Pregnancy, breastfeeding
- Unable to provide consent
- Current smoking, tobacco, nicotine use
- Body weight change \>10% within the last 6 months
- Adherence to \>150 min/week of moderate-to-vigorous physical activity/exercise
- Claustrophobia
Who the study is looking for
- 18 to 65 years of age
- Individuals with obesity and comorbid IR
- BMI 30-45 kg/m2
- Waist circumference ≥102 cm (men) or ≥88 cm (women)
- HOMA-IR ≥2.5
- Healthy normal weight adults
- BMI 18-25 kg/m2
- Waist circumference \<94 cm (men) and \<80 cm (women)
- HOMA-IR \<2
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Missouri Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.