NCT07653750Terminated
Study on Variation of Serum and Fecal Biomarkers After Treatment to Predict Mucosal Healing in Patients With Ulcerative Colitis
Source: ClinicalTrials.gov · Last updated 17 Jun 2026
Brief summary (registry, in English)
Mucosal healing is recognized hitherto as the best therapeutic endpoint in patients with Ulcerative Colitis (UC) but its use in daily practice is limited by the low acceptability of repeated colonoscopies. In this context, fecal biomarkers are attractive alternatives. Fecal calprotectin showed very good negative predictive value to eliminate IBD diagnosis, good correlation to endoscopic activity and good ability to predict relapse. Recently, several teams including ours, showed that fecal biomarkers such as Chitinase 3-Like 1 (CHI3L1), matrix metalloprotease type 9 (MMP-9) and serum biomarkers neutrophil gelatinase B- complex associated lipocalin (NGAL)-MMP9 and serum CHI3L1 could be better biomarkers than fecal calprotectin to assess endoscopic activity in patients with UC.
- Status (registry)
- Terminated
- Study type
- Interventional
- Enrollment
- 62 (actual)
- First submitted
- 29 Jun 2018
- Start date
- 25 Jun 2021
- Primary completion date
- 9 Jun 2026
- Lead sponsor
- University Hospital, Clermont-Ferrand
- Diseases
- Ulcerative colitis
- NCT number
- NCT07653750
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patient wishing to discontinue participation in the study for any reason
- Study exit at the investigator's discretion
- Pregnancy Discovery
Who the study is looking for
- Patients with Ulcerative Colitis
- Age ≥ 18 years
- Presence of endoscopic activity (Mayo endoscopic score ≥ 2) requiring the introduction, increase or change of treatment
- Patients able to consent
- Non Inclusion Criteria :
- Patients not affiliated to the social security system
- Pregnant or breastfeeding woman
- Patients who have total coloproctectomy with ileo-anal anastomosis
- Acute Severe Ulcerative Colitis (ASUC)
- Persons under guardianship, trusteeship or imprisonment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Clermont-Ferrand Coordinator of this site? Confirm its status | Clermont-Ferrand | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.