NCT07653880Completed
Virtual Reality-Assisted Exercise in Pediatric Hematopoietic Stem Cell Transplantation
Effects of Virtual Reality-Assisted Video Game-Based Exercise Training on Functional Level, Respiratory Parameters, and Physical Fitness in Pediatric Patients After Hematopoietic Stem Cell Transplantation
Source: ClinicalTrials.gov · Last updated 17 Jun 2026
Brief summary (registry, in English)
This randomized controlled, single-blind clinical trial investigates whether virtual reality (VR)-assisted, video game-based exercise training, added to a conventional pulmonary physiotherapy and rehabilitation program, improves functional level, respiratory parameters, and physical fitness in pediatric patients (5-18 years) following hematopoietic stem cell transplantation (HSCT). Participants attended 24 supervised, face-to-face exercise sessions over 8 weeks (3×/week) under physiotherapist supervision. The Experimental Group received game-based exercise using the Nintendo Wii Fit U platform with the Wii Balance Board and the Breathing Labs Breathing Games software (Slovenia) in addition to the conventional program. Outcomes included the Modified Alpha-Fit Pediatric Test Battery (vertical jump, 6-minute walk test, sit-and-reach, flamingo balance), upper-extremity isometric muscle strength (handheld dynamometry) and handgrip strength (Jamar), pulmonary function tests, maximal inspiratory and expiratory mouth pressures, accessory respiratory muscle architecture by myotonometry (MyotonPro: sternocleidomastoid, upper trapezius, pectoralis major), and ultrasound assessment of pleural thickness, diaphragm thickness, and diaphragm excursion.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 38 (actual)
- First submitted
- 29 Apr 2026
- Start date
- 16 Jan 2025
- Primary completion date
- 30 Aug 2025
- Lead sponsor
- Istinye University
- Diseases
- Childhood cancers
- NCT number
- NCT07653880
What you commit to
- Study type: Interventional
- Participants enrolled: 38
- From 16 Jan 2025 to the primary completion date, 30 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe visual impairment or visual field defects.
- History of abdominal or thoracic surgery.
- During study: medically unstable status; new diagnosis of cutaneous graft-versus-host disease (GvHD) requiring high-dose steroid therapy; respiratory-tract or systemic infection requiring isolation; new psychiatric illness with poor prognosis; relocation precluding follow-up; withdrawal of consent.
Other
- Facial palsy.
- Aphasia.
Who the study is looking for
- Currently receiving care in a pediatric bone marrow transplantation unit (post-HSCT).
- Age between 5 and 18 years (inclusive).
- Able to perform pursed-lip breathing with expiration ≥ 3 seconds.
- Ambulatory and able to cooperate with verbal instructions.
- Clinically stable as confirmed by the treating physician at the time of enrollment.
- No history of orthopedic, neurological, or cardiac disease.
Age in the registry: 5 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| İstinye University Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.