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NCT07654374RecruitingPhase 3

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

A Long-Term Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Multiple Maintenance Doses of Oral Once Daily Aleniglipron for Chronic Weight Management in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Source: ClinicalTrials.gov · Last updated 20 Oct 2026

Brief summary (registry, in English)

This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM. Participants will be randomized to aleniglipron or placebo for a total of 76 weeks of treatment.

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
1100 (estimated)
First submitted
12 Jun 2026
Start date
17 Jul 2026
Primary completion date
30 Sept 2028
Lead sponsor
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
NCT number
NCT07654374

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 1100
  • From 17 Jul 2026 to the primary completion date, 30 Sept 2028
  • 70 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 180 days prior to Screening.
  • Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema
  • Self-reported change in body weight \>5 kg (11 pounds) within 3 months before Screening.
  • Have prior or planned surgical or non-surgical treatment for obesity.

Other illness

  • Have type 1 diabetes, history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2DM.

Who the study is looking for

  • Signed Informed Consent
  • Have a BMI ≥27.0 kg/m2 at Screening
  • Have a diagnosis of T2DM according to the WHO classification or other locally applicable standards, with HbA1c ≥6.5% (≥53 mmol/mol) to ≤10% (86 mmol/mol) at Screening

Age in the registry: 18 years to 79 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (70)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
AlbanyUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
AtlantaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
AustinUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
BirminghamUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
BrooklynUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
BurkeUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
ChandlerUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
CharlotteUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
ChesterfieldUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
City of Saint PetersUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
ClearwaterUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
ColumbusUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Des MoinesUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
DurhamUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
EscondidoUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Farmers BranchUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
FayettevilleUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Fort MyersUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Fountain ValleyUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
GreerUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
GulfportUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
HazelwoodUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
HoustonUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Iowa CityUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
JacksonvilleUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
La JollaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Lake ForestUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Las VegasUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
LawrencevilleUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
LeesburgUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Little RockUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
ManassasUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MankatoUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MeridianUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MethuenUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MiamiUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MinneapolisUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MissoulaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
MooreUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Morehead CityUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
NashvilleUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
OcalaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
OcoeeUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
OmahaUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Pembroke PinesUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
PhiladelphiaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
PhoenixUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
PortlandUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
RentonUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
RidgelandUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Rolling Hills EstatesUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Salt Lake CityUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
San AntonioUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
San DiegoUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Silver SpringUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
SpringfieldUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
St LouisUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
SuffolkUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Sun City WestUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
The BronxUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
TucsonUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
TulsaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
TustinUnited StatesNot yet recruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Union CityUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
WaterburyUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
WichitaUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
Winston-SalemUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
WoodstockUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
WylieUnited StatesRecruiting
ACCOMPLISH-2 Research Site
Coordinator of this site? Confirm its status
YukonUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.