NCT07656051Not yet recruiting
Taurine and Nitrate Supplementation on Thermoregulatory in T2DM
The Effect of Taurine and Nitrate Supplementation on Thermoregulatory Responses in People With Type 2 Diabetes Mellitus.
Source: ClinicalTrials.gov · Last updated 18 Jun 2026
Brief summary (registry, in English)
Anthropogenic warming is increasing the frequency and intensity of extreme heat events. Elevated temperatures raise the risk of mortality and hospital admissions, particularly among people with chronic illnesses such as type 2 diabetes mellitus (T2DM). Globally, around 530 million people live with T2DM , and in the United Kingdom nearly six million are affected, creating a substantial population vulnerable to heat related illness. People with T2DM are at heightened risk of cardiovascular disease, which can impair cardiac output, a key component of thermoregulation, as it supports increased skin blood flow for heat dissipation. T2DM also attenuates eccrine sweat gland function, peripheral vasodilation, reducing evaporative cooling capacity. These physiological constraints highlight the need for effective strategies to improve heat tolerance in this group. Recent evidence shows that exogenous taurine supplementation can enhance sweating in healthy individuals, potentially improving heat loss. This study will examine whether acute taurine supplementation, alone or combined with beetroot, can limit rises in core temperature in people with T2DM during an acute extreme heat exposure.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 8 May 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 1 Apr 2028
- Lead sponsor
- University of Portsmouth
- Diseases
- Type 2 diabetes
- NCT number
- NCT07656051
What you commit to
- Study type: Interventional
- Planned participants: 18
- From 1 Jun 2026 to the primary completion date, 1 Apr 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking any medication which may interfere with data interpretation or safety
- Prior heat related illness
Other illness
- Uncontrolled hypertension (≥180 systolic / 100 diastolic)
- Who have had a myocardial infarction or cerebrovascular event
- Any cardiac abnormalities which restrict hard exercise
- Any allergies to the ingredients used in the supplements
- Any serious medical condition which would interfere with data interpretation or safety will be excluded from participation.
- Pre-existing postural hypertension
- Existing cardiac diseases (identified during screening)
Lab values
- Significant renal impairment (eGFR \< 30)
Other
- Severe peripheral neuropathy (to the point to which they cannot sense temperature)
- Diagnosed anhidrosis
- BMI \>40
- Current smokers or who have stopped within 3 months
- Unable to understand and/or fully cooperate with the study protocol
- Open wounds
- Skin ulcerations (that would interfere with data collection and interpretation or safety)
- Eczema (that would interfere with data collection and interpretation or safety)
- Currently heat acclimated (repeated exposure to hot environments ≥3 sessions in the last 14-21 days)
Who the study is looking for
- Male or female (post-menopausal) aged 35 years or above.
- Diagnosed with T2DM as defined by the WHO (HbA1c ≥48 mmol/mol).
- Willing and able to give informed consent for participation in the study.
- Able to understand and fully cooperate with the study protocol.
Age in the registry: 35 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.