NCT07657624Recruiting
Modifiable Risk Factors for Cognitive Dysfunction in Patients With Coronary Heart Disease
Association Between Modifiable Risk Factors and Cognitive Function in Patients With Coronary Heart Disease
Source: ClinicalTrials.gov · Last updated 15 Jul 2026
Brief summary (registry, in English)
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2352 (estimated)
- First submitted
- 15 Jun 2026
- Start date
- Jun 2025
- Primary completion date
- May 2031
- Lead sponsor
- Beijing Anzhen Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07657624
What you commit to
- Study type: Observational
- Planned participants: 2352
- From Jun 2025 to the primary completion date, May 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously diagnosed dementia.
Other illness
- History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment.
- Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
Other
- Pregnancy or breastfeeding.
Who the study is looking for
- Age ≥ 18 years
- Diagnosis of coronary heart disease (meeting at least one of the following):
- Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery;
- Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment;
- Objective evidence of myocardial ischemia or typical clinical symptoms
- Completion of standardized neuropsychological assessment during hospitalization
- Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
- Provision of signed written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Anzhen Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.