NCT07659288Completed
Comparison of Immersive and Non-Immersive Virtual Reality Rehabilitation in Parkinson's Disease
Differential Motor and Cognitive Responses to Two Virtual Reality-Based Rehabilitation Approaches in Parkinson's Disease: A Pilot Comparative Study
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
Parkinson's disease commonly affects walking ability, balance, mobility, and cognitive function, increasing the risk of falls and reducing independence. Virtual reality (VR) has emerged as a promising rehabilitation tool, but the potential differences between immersive and non-immersive VR approaches remain unclear. This pilot randomized comparative study aims to evaluate the feasibility, safety, and preliminary effects of immersive virtual reality (IVR) and non-immersive virtual reality (NIVR) rehabilitation in individuals with Parkinson's disease. Participants will be assigned to either an immersive VR intervention using a head-mounted display or a non-immersive VR intervention using a tablet-based exergaming platform. Both interventions will be delivered over six weeks and will target gait, balance, mobility, motor-cognitive interaction, and functional performance. Outcomes will include gait parameters, functional mobility, freezing of gait, cognitive function, adherence, and safety. The findings will help determine whether different VR modalities produce distinct motor and cognitive responses and will inform the design of future larger clinical trials.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 16 (actual)
- First submitted
- 15 Jun 2026
- Start date
- 10 Sept 2025
- Primary completion date
- 27 Sept 2025
- Lead sponsor
- Neuro Group XR Inc.
- Diseases
- Parkinson disease
- NCT number
- NCT07659288
What you commit to
- Study type: Interventional
- Participants enrolled: 16
- From 10 Sept 2025 to the primary completion date, 27 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous deep brain stimulation.
Other illness
- Diagnosis of other neurological or movement disorders.
- Severe cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score \<18.
- Severe visual impairment not correctable with lenses.
- History of epilepsy.
- Uncontrolled psychiatric disorders.
Who the study is looking for
- Age between 45 and 75 years.
- Diagnosis of idiopathic Parkinson's disease.
- Hoehn and Yahr stage between 1.5 and 4.
- Ability to walk independently or with an assistive device (cane or walker).
- Low to moderate fall risk, defined as a Timed Up and Go (TUG) score \<20 seconds.
- Ability to provide written informed consent.
Age in the registry: 45 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás Coordinator of this site? Confirm its status | La Serena | Chile | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.