NCT07663773Not yet recruiting
Thyroid Hormones in CKD
Deciphering the Role of Thyroid Hormones in Severe Non-ADPKD Chronic Kidney Disease
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
This is a retrospective, observational, study evaluating circulating thyroid hormone profiles in patients with severe chronic kidney disease (CKD stages G4-G5, non-dialysis). The study includes one cohort of patients with non-ADPKD CKD and a second including a matched subset of patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) at the same CKD stage,. For the non-ADPKD CKD group, serum and urine samples will be retrieved from the certified biobank of the Centro Daccò (Mario Negri IRCCS). For the ADPKD group, analyses will be performed exclusively using existing clinical and laboratory data available within the REORIENTED study database. Laboratory measurements will be performed on stored biological samples from the non-ADPKD CKD group to assess thyroid hormones (rT3, fT3, tT3, fT4, tT4, and TSH). Clinical and laboratory data for both cohorts will be obtained from the respective study databases and linked within a predefined temporal window relative to sample collection (where applicable).
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 51 (estimated)
- First submitted
- 15 Jun 2026
- Start date
- Sept 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Mario Negri Institute for Pharmacological Research
- Diseases
- Chronic kidney disease
- NCT number
- NCT07663773
What you commit to
- Study type: Observational
- Planned participants: 51
- From Sept 2026 to the primary completion date, Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with thyroid hormone replacement or antithyroid drugs
- Use of medications known to interfere with thyroid function (e.g., amiodarone, lithium, interferon)
- Systemic corticosteroid or immunosuppressive therapy at the time of sampling (if data available)
Other illness
- Known history of thyroid disease (hypothyroidism, hyperthyroidism, thyroiditis, or thyroid cancer)
- Dialysis treatment or history of kidney transplantation at the time of sampling
- Acute illness, infection, or hospitalization close to the time of sample collection (if identifiable)
Who the study is looking for
- Non-ADPKD CKD
- CKD stage G4, included in the ADAPT study
- Availability of stored serum and urine samples in the biobank suitable for thyroid hormone analysis
- Availability of relevant clinical and laboratory data within a predefined time window from sample collection
- Signed informed consent for storage and future research use of biological samples and clinical data
- ADPKD CKD
- CKD stage G4, included in the REORIENTED study
- Availability of complete thyroid hormone profile and relevant clinical data
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Research Centre for Rare Diseases Aldo e Cele Daccò Coordinator of this site? Confirm its status | Ranica | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.