NCT07664124Not yet recruiting
Digital Monitoring of Upper Limb Function in Non-Ambulant DMD
Feasibility, Reliability, Clinical Validity and Sensitivity of Digital Outcomes to Monitor Upper Limb Function in Non-ambulant Patients With Genetically Confirmed Duchenne Muscular Dystrophy (DMD)
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
Duchenne Muscular Dystrophy (DMD) is a rare genetic disorder caused by the absence of dystrophin, leading to progressive muscle degeneration. Symptoms typically begin in early childhood and result in loss of ambulation by early adolescence, followed by cardiorespiratory complications. Although early treatment, including corticosteroids and emerging therapies, can slow disease progression, sensitive tools to monitor functional decline-particularly in non-ambulant patients-remain limited. Current assessments rely primarily on clinical scales and hospital-based evaluations, which may not detect subtle changes or reflect real-life function. Digital outcome measures derived from wearable sensors offer a promising approach for continuous, objective monitoring in daily life. This study aims to evaluate the feasibility, reliability, clinical validity, and sensitivity of digital measures to assess upper limb function in non-ambulant patients with genetically confirmed DMD. The Syde device, previously validated in ambulant DMD patients, will be investigated for its applicability in this population.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 15 Jun 2026
- Start date
- Jul 2026
- Primary completion date
- Jun 2029
- Lead sponsor
- Centre Hospitalier Universitaire de Liege
- Diseases
- Duchenne muscular dystrophy
- NCT number
- NCT07664124
What you commit to
- Study type: Interventional
- Planned participants: 50
- From Jul 2026 to the primary completion date, Jun 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Scoliosis surgery within the previous 6 months or planned within the next year
Other illness
- Any acute or chronic condition that, in the opinion of the investigator, may significantly interfere with the assessments and/or motor function progression.
Other
- Participation in an interventional clinical trial.
- No access to internet connection or alternatively no capacity to come on-site to bring the Syde every 6 months after the recording periods for data retrieval by Liège team
Who the study is looking for
- Patient with genetically confirmed Duchenne Muscular Dystrophy (DMD).
- Non-ambulant at the time of inclusion (not able to walk 10m without external aid).
- A legal guardian willing and able to provide written informed consent for participation in the study if \< 18 years old.
Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre de référence des maladies neuromusculaire, Centre Hospitalier Régional de la Citadelle Coordinator of this site? Confirm its status | Liège | Belgium | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.