NCT07666477Completed
rTMS and Olfactory Training for Parkinson's Disease
Synergistic Effects of Combined Repetitive Transcranial Magnetic Stimulation and Olfactory Training on Chemosensory Recovery in Parkinson's Disease: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 26 Jun 2026
Brief summary (registry, in English)
Background: Olfactory and gustatory impairments are common clinical manifestations in patients with neurodegenerative conditions like Parkinson's disease. These chemosensory deficits significantly impact the quality of life, often preceding motor symptoms. Currently, there is a need for effective non-invasive interventions to improve sensory recovery. Objective: The primary objective of this study is to evaluate the therapeutic efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) combined with olfactory training in restoring chemosensory function. We aim to determine whether this combined approach provides superior outcomes compared to individual therapies or standard care. Methods: This clinical trial involves 120 patients diagnosed with Parkinson's disease. Participants will be randomized into four groups to receive either combined rTMS and olfactory training, isolated rTMS, isolated olfactory training, or a control intervention. The recovery of olfactory function will be measured using validated sensory testing tools (such as Sniffin' Sticks) and Electrogustometry (EGM) to assess neural pathway improvement. Conclusion/Significance: This study aims to provide evidence-based insights into non-invasive neurological rehabilitation for chemosensory dysfunction. The findings may help optimize personalized treatment protocols for patients suffering from sensory impairment, potentially enhancing their overall cognitive and sensory quality of life.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 120 (actual)
- First submitted
- 18 Jun 2026
- Start date
- 2 Jan 2026
- Primary completion date
- 15 May 2026
- Lead sponsor
- Mustafa Baran
- Diseases
- Parkinson disease
- NCT number
- NCT07666477
What you commit to
- Study type: Interventional
- Participants enrolled: 120
- From 2 Jan 2026 to the primary completion date, 15 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of cranial metal implants or cardiac pacemakers (absolute contraindications for rTMS).
- Severe psychiatric disorders.
- Advanced dementia.
- History of nasal polyps or active sinusitis that could mechanically obstruct olfactory pathways.
Other
- Pregnancy.
Who the study is looking for
- Patients aged between 40 and 75 years.
- Confirmed diagnosis of idiopathic Parkinson's disease (PD) according to the Movement Disorder Society (MDS) clinical diagnostic criteria.
- Confirmed olfactory dysfunction validated by the Sniffin' Sticks test at baseline (defined as a composite TDI score ≤ 30.5 for hyposmia and \< 16.0 for functional anosmia).
Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Batman University Coordinator of this site? Confirm its status | Batman | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.