NCT07668414RecruitingPhase 3
A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 650 (estimated)
- First submitted
- 19 Jun 2026
- Start date
- 22 Sept 2026
- Primary completion date
- 10 Oct 2028
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT07668414
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 650
- From 22 Sept 2026 to the primary completion date, 10 Oct 2028
- 45 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.
Other illness
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
Lab values
- Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening.
Who the study is looking for
- Male or female (sex at birth).
- Age 18 years or above at the time of signing the informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (45)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amarillo Med Spec LLP Coordinator of this site? Confirm its status | Amarillo | United States | Recruiting |
| Conquest Research Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Texas Diabetes & Endocrinology Coordinator of this site? Confirm its status | Austin | United States | Recruiting |
| Pinnacle Clinical Research Coordinator of this site? Confirm its status | Brownsville | United States | Recruiting |
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Chicago Research Center Inc. Coordinator of this site? Confirm its status | Chicago | United States | Not yet recruiting |
| Osvaldo A. Brusco MD Coordinator of this site? Confirm its status | Corpus Christi | United States | Recruiting |
| UT Southwestern Med Center Coordinator of this site? Confirm its status | Dallas | United States | Not yet recruiting |
| Geisinger Clinic Coordinator of this site? Confirm its status | Danville | United States | Recruiting |
| Epic Medical Research Coordinator of this site? Confirm its status | DeSoto | United States | Not yet recruiting |
| Lillestol Research, LLC Coordinator of this site? Confirm its status | Fargo | United States | Recruiting |
| PharmQuest Life Sciences LLC Coordinator of this site? Confirm its status | Greensboro | United States | Not yet recruiting |
| Encore Medical Research LLC Coordinator of this site? Confirm its status | Hollywood | United States | Recruiting |
| NextPhase Research Coordinator of this site? Confirm its status | Hollywood | United States | Recruiting |
| The Endocrine Center Coordinator of this site? Confirm its status | Houston | United States | Not yet recruiting |
| Houston Research Institute Coordinator of this site? Confirm its status | Houston | United States | Not yet recruiting |
| Midwest Inst For Clin Res Coordinator of this site? Confirm its status | Indianapolis | United States | Recruiting |
| Jacksonville Ctr Clin Res Coordinator of this site? Confirm its status | Jacksonville | United States | Not yet recruiting |
| First Valley Medical Group Coordinator of this site? Confirm its status | Lancaster | United States | Recruiting |
| PharmaDev Clinical Research Institute, LLC Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| South Broward Research LLC Coordinator of this site? Confirm its status | Miramar | United States | Recruiting |
| Essence MD Research Coordinator of this site? Confirm its status | Naples | United States | Not yet recruiting |
| Florida Inst For Clin Res LLC Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Oviedo Medical Research, LLC Coordinator of this site? Confirm its status | Oviedo | United States | Recruiting |
| Desert Oasis Healthcare Coordinator of this site? Confirm its status | Palm Springs | United States | Recruiting |
| Western University of Health Sciences Coordinator of this site? Confirm its status | Pomona | United States | Recruiting |
| Rainier Clin Res Ctr Inc Coordinator of this site? Confirm its status | Renton | United States | Recruiting |
| National Clin Res Inc. Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| Gastroent Consult of SW VA Coordinator of this site? Confirm its status | Roanoke | United States | Not yet recruiting |
| Sleep Therapy Research Center Coordinator of this site? Confirm its status | San Antonio | United States | Not yet recruiting |
| Artemis Insitute for Clin Res Coordinator of this site? Confirm its status | San Diego | United States | Recruiting |
| Seattle Clinical Research Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Hillcrest Clinical Research Coordinator of this site? Confirm its status | Simpsonville | United States | Recruiting |
| Endeavor Health Coordinator of this site? Confirm its status | Skokie | United States | Recruiting |
| Eastside Bariatric and Gen Surg Coordinator of this site? Confirm its status | Snellville | United States | Recruiting |
| Spartanburg Medical Research Coordinator of this site? Confirm its status | Spartanburg | United States | Recruiting |
| Piedmont Healthcare/Research Coordinator of this site? Confirm its status | Statesville | United States | Recruiting |
| Amicis Centers of Clinical Research Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Olympus Clinical Research Coordinator of this site? Confirm its status | Sugar Land | United States | Not yet recruiting |
| Ichor Research Coordinator of this site? Confirm its status | Syracuse | United States | Recruiting |
| Med Home Development Grp Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| Encore Medical Research of Weston Coordinator of this site? Confirm its status | Weston | United States | Recruiting |
| Palm Beach Research Center Coordinator of this site? Confirm its status | West Palm Beach | United States | Recruiting |
| Southgate Medical Group, LLP Coordinator of this site? Confirm its status | West Seneca | United States | Recruiting |
| Southern Clin Research Coordinator of this site? Confirm its status | Zachary | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.