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NCT07668414RecruitingPhase 3

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

Efficacy and Safety of Zenagamtide s.c. Once-weekly Compared to Semaglutide s.c. Once-weekly in Participants With Obesity (AMAZE 7)

Source: ClinicalTrials.gov · Last updated 28 Sept 2026

Brief summary (registry, in English)

The purpose of this study is to find out if zenagamtide is safe and effective for treating participants who have excess body weight compared to treatment with semaglutide.

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
650 (estimated)
First submitted
19 Jun 2026
Start date
22 Sept 2026
Primary completion date
10 Oct 2028
Lead sponsor
Novo Nordisk A/S
Diseases
Obesity
NCT number
NCT07668414

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 650
  • From 22 Sept 2026 to the primary completion date, 10 Oct 2028
  • 45 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues within 1 year before screening.

Other illness

  • History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.

Lab values

  • Glycated haemoglobin (HbA1c) ≥ 6.5% (48 millimoles per mole \[mmol/mol\]) as measured by the central laboratory at screening.

Who the study is looking for

  • Male or female (sex at birth).
  • Age 18 years or above at the time of signing the informed consent.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (45)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Amarillo Med Spec LLP
Coordinator of this site? Confirm its status
AmarilloUnited StatesRecruiting
Conquest Research
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AtlantaUnited StatesRecruiting
Texas Diabetes & Endocrinology
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AustinUnited StatesRecruiting
Pinnacle Clinical Research
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BrownsvilleUnited StatesRecruiting
Medical University of South Carolina
Coordinator of this site? Confirm its status
CharlestonUnited StatesRecruiting
Chicago Research Center Inc.
Coordinator of this site? Confirm its status
ChicagoUnited StatesNot yet recruiting
Osvaldo A. Brusco MD
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Corpus ChristiUnited StatesRecruiting
UT Southwestern Med Center
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DallasUnited StatesNot yet recruiting
Geisinger Clinic
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DanvilleUnited StatesRecruiting
Epic Medical Research
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DeSotoUnited StatesNot yet recruiting
Lillestol Research, LLC
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FargoUnited StatesRecruiting
PharmQuest Life Sciences LLC
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GreensboroUnited StatesNot yet recruiting
Encore Medical Research LLC
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HollywoodUnited StatesRecruiting
NextPhase Research
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HollywoodUnited StatesRecruiting
The Endocrine Center
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HoustonUnited StatesNot yet recruiting
Houston Research Institute
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HoustonUnited StatesNot yet recruiting
Midwest Inst For Clin Res
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IndianapolisUnited StatesRecruiting
Jacksonville Ctr Clin Res
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JacksonvilleUnited StatesNot yet recruiting
First Valley Medical Group
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LancasterUnited StatesRecruiting
PharmaDev Clinical Research Institute, LLC
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MiamiUnited StatesRecruiting
South Broward Research LLC
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MiramarUnited StatesRecruiting
Essence MD Research
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NaplesUnited StatesNot yet recruiting
Florida Inst For Clin Res LLC
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OrlandoUnited StatesRecruiting
Oviedo Medical Research, LLC
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OviedoUnited StatesRecruiting
Desert Oasis Healthcare
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Palm SpringsUnited StatesRecruiting
Western University of Health Sciences
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PomonaUnited StatesRecruiting
Rainier Clin Res Ctr Inc
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RentonUnited StatesRecruiting
National Clin Res Inc.
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RichmondUnited StatesRecruiting
Gastroent Consult of SW VA
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RoanokeUnited StatesNot yet recruiting
Sleep Therapy Research Center
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San AntonioUnited StatesNot yet recruiting
Artemis Insitute for Clin Res
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San DiegoUnited StatesRecruiting
Seattle Clinical Research Center
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SeattleUnited StatesRecruiting
Hillcrest Clinical Research
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SimpsonvilleUnited StatesRecruiting
Endeavor Health
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SkokieUnited StatesRecruiting
Eastside Bariatric and Gen Surg
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SnellvilleUnited StatesRecruiting
Spartanburg Medical Research
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SpartanburgUnited StatesRecruiting
Piedmont Healthcare/Research
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StatesvilleUnited StatesRecruiting
Amicis Centers of Clinical Research
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St LouisUnited StatesRecruiting
Olympus Clinical Research
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Sugar LandUnited StatesNot yet recruiting
Ichor Research
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SyracuseUnited StatesRecruiting
Med Home Development Grp
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Washington D.C.United StatesRecruiting
Encore Medical Research of Weston
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WestonUnited StatesRecruiting
Palm Beach Research Center
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West Palm BeachUnited StatesRecruiting
Southgate Medical Group, LLP
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West SenecaUnited StatesRecruiting
Southern Clin Research
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ZacharyUnited StatesNot yet recruiting

This page is information, not medical advice. Discuss any trial with your doctor.