NCT07670091Active, not recruiting
Endothelin Role In COronary Microcirculation
Determining the Role of Endothelin in Microcirculatory Function in Myocardial Ischaemia
Source: ClinicalTrials.gov · Last updated 26 Jun 2026
Brief summary (registry, in English)
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries. Previous studies suggest that endothelin-1, a naturally occurring substance that causes blood vessel constriction, may contribute to abnormalities in the coronary microcirculation. The ERICOM study aims to investigate whether treatment with bosentan, an endothelin receptor antagonist, can improve coronary microvascular function in patients with angina and evidence of coronary microvascular dysfunction. Participants undergo cardiovascular magnetic resonance (CMR) imaging before and after treatment, and some participants also undergo invasive coronary physiological assessment. The results of this study may improve understanding of the role of endothelin-1 in coronary microvascular dysfunction and help identify new treatment strategies for patients with angina and non-obstructive coronary artery disease.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 19 Jun 2026
- Start date
- 1 Jul 2023
- Primary completion date
- 31 Jul 2025
- Lead sponsor
- Liverpool University Hospitals NHS Foundation Trust
- Diseases
- Coronary artery disease
- NCT number
- NCT07670091
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 1 Jul 2023 to the primary completion date, 31 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Known significant coronary artery disease, defined as previous investigations demonstrating greater than 50% epicardial coronary artery stenosis.
- Uncontrolled hypertension, defined as clinic blood pressure greater than 140/90 mmHg despite treatment with three or more antihypertensive medications.
- Previously documented allergy or hypersensitivity to endothelin receptor antagonists.
- Concurrent use of medications contraindicated with endothelin receptor antagonist therapy.
Other illness
- Symptoms consistent with unstable angina, including:
- Angina at rest lasting more than 20 minutes.
- New-onset severe angina.
- Angina increasing in frequency, duration, or occurring at a lower threshold.
- Angina occurring following a recent myocardial infarction.
- Severe heart failure or symptoms of active heart failure.
- Clinical evidence of active infection at the time of recruitment.
- Significant liver disease, defined as Child-Pugh Class B or C liver disease (or worse than Child-Pugh Class A).
- Requirement for invasive coronary angiography for another clinical indication, including but not limited to valvular heart disease assessment or intervention.
Lab values
- Significant chronic kidney disease, defined as estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m².
Other
- Pregnancy or breastfeeding.
- Poorly controlled asthma as defined in the study protocol.
- Systolic blood pressure less than 90 mmHg at the time of recruitment.
Who the study is looking for
- Clinical diagnosis of symptomatic angina, defined as the presence of substernal chest pain or discomfort provoked by exertion or emotional stress and relieved by rest and/or glyceryl trinitrate (nitroglycerin).
- Age 18 years or older.
- Able and willing to provide written informed consent.
- Able and willing to adhere to study procedures and follow-up requirements.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NHS University Hospitals of Liverpool Group Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.