NCT07673770Recruiting
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker. In people with dementia, it gets much worse, making it harder to talk with others, follow directions, or remember things like shopping lists. This may happen because brain waves that support working memory fall out of sync. Researchers can see these brain waves using a test called EEG. In this study, the investigators will try to get these brain waves back in sync using a safe, non-invasive form of brain stimulation called transcranial magnetic stimulation (TMS), and will time it to each person's brain waves to make it more effective. The goal is to improve working memory in people with dementia. If successful, dementia patients may be able to be more independent taking pressure off their families.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 10 Apr 2026
- Start date
- 7 Jul 2026
- Primary completion date
- 1 Apr 2028
- Lead sponsor
- McMaster University
- Diseases
- Alzheimer disease
- NCT number
- NCT07673770
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 7 Jul 2026 to the primary completion date, 1 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contraindications to TMS; presence of a pacemaker, metal/electrical/magnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure.
- Allergy to rubbing alcohol, which is needed to prepare electromyography for TMS
Who the study is looking for
- Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician.
- Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE
- Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English.
- Individuals must be at least 55 years or older
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ivor Wynne Center Coordinator of this site? Confirm its status | Hamilton | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.