NCT07674264Recruiting
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
A Pilot Study of Acute Intermittent Hypercapnia-Based Interventions on Upper Airway and Axial Motor Function in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 32 (estimated)
- First submitted
- 16 Jun 2026
- Start date
- 12 Aug 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- University of Florida
- Diseases
- Parkinson disease
- NCT number
- NCT07674264
What you commit to
- Study type: Interventional
- Planned participants: 32
- From 12 Aug 2026 to the primary completion date, 31 Dec 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- additional neurologic conditions
- severe illness or infection, including respiratory/cardiovascular/lung disease, or uncontrolled hypertension
- history of head/neck/lung cancer with the exception of basal cell carcinoma
- has deep brain stimulation electrodes implanted or has a history of deep brain stimulation
Age
- pregnancy due to unknown tAIH effects on a fetus, although females of childbearing age will not be excluded\*
Other
- inspiratory stridor
- cigarette smoking or vaping within 5 years
- is currently participating in another research study that could influence the results from this study
- faints or becomes lightheaded at the sight of blood
- If a female of childbearing potential indicates there is a chance she could be pregnant, she will be provided a pregnancy test and allowed to continue in the study if negative. This is because the fetal risks associated with intermittent hypoxia are unknown.
Who the study is looking for
- adults 40 to 75 years of age (the latter to reduce the likelihood of cardiovascular disease)
- diagnosis of idiopathic Parkinsonism with Hoehn and Yahr stages 2-4
- medically stable with physician clearance
- ability to ambulate at least 10 feet with/without assistance
- ability to follow directions
- willing to abstain from blood donation for the duration of the study
Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
| Norman Fixel Institute for Neurological Diseases Coordinator of this site? Confirm its status | Gainesville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.