NCT07675382Completed
NMES Plus Hypocaloric Diet: Body Composition, Cardiometabolic Markers, Irisin and Betatrophin in Women With Obesity
Effects of Neuromuscular Electrical Stimulation Combined With a Hypocaloric Diet on Body Composition, Cardiometabolic Markers, Irisin and Betatrophin in Women With Obesity: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
This randomized controlled trial evaluated whether adding localized neuromuscular electrical stimulation (NMES) to an individualized hypocaloric diet changes serum irisin and betatrophin (ANGPTL8) concentrations, body composition and cardiometabolic markers in women with obesity, compared with the diet alone. Forty-four women aged 18-65 years with a body mass index (BMI) of 30 kg/m2 or more were randomly assigned (1:1) to a diet-only group or a diet plus NMES group. NMES was applied to the abdominal and gluteal muscles twice weekly for six weeks (12 sessions of 20-25 minutes). The primary outcomes were the changes in serum irisin and betatrophin; the secondary outcomes were the changes in body weight, BMI, body fat percentage, fat mass, skeletal muscle mass and cardiometabolic markers, assessed at baseline and at the end of week 6.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 44 (actual)
- First submitted
- 17 Jun 2026
- Start date
- 2 Feb 2025
- Primary completion date
- 24 Aug 2025
- Lead sponsor
- Firat University
- Diseases
- Obesity
- NCT number
- NCT07675382
What you commit to
- Study type: Interventional
- Participants enrolled: 44
- From 2 Feb 2025 to the primary completion date, 24 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications known to alter appetite or body composition (e.g., high-dose glucocorticoids, anti-obesity medications)
Other illness
- Implantable cardiac device (e.g., pacemaker or implantable cardioverter-defibrillator)
- History of cardiovascular disease
- End-stage renal or hepatic failure
- Active malignancy
- Acute infection
- Severe orthopaedic conditions precluding physical exercise
- Severe psychiatric or cognitive impairment
Other
- Pregnancy or lactation
- Advanced or uncontrolled diabetic complications
- Regular resistance training (more than 45 minutes per week) within the preceding three months
- Body weight change of 5% or more within the preceding three months
- Excessive alcohol consumption or substance dependence
Who the study is looking for
- Women aged 18-65 years
- Obesity according to World Health Organization criteria (BMI \>= 30 kg/m2)
- Sedentary lifestyle (less than two hours of regular exercise per week)
- Written informed consent
- Mild-to-moderate comorbidities (e.g., hypertension managed by diet or monotherapy) were permitted if participation was deemed medically safe by the investigators
Age in the registry: 18 years to 65 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dicle University, Department of Nutrition and Dietetics Coordinator of this site? Confirm its status | Diyarbakır | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.