NCT07675824RecruitingPhase 1/2
REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular Hypertension
A Phase 1/2 Study of REGN22530 in Participants With Primary Open Angle Glaucoma or Ocular Hypertension
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
This study will test an experimental drug called REGN22530 ("study drug") to see if it can help treat people with primary open angle glaucoma or ocular hypertension. REGN22530 is an experimental drug that is designed to bind with a protein in the eye that has been shown to cause a buildup of fluid inside the eye and cause increased Intraocular Pressure (IOP). REGN22530 attaches to this protein and stops it from working which may allow more fluid to drain out of the eye and decrease the pressure. The study is looking at: * What side effects REGN22530 might cause * How much REGN22530 is in the blood and eye fluid at different times * If the body has any reactions to REGN22530 (which may cause REGN22530 to not work as well) * How the body and eye pressure respond after having REGN22530, which can help researchers understand why REGN22530 works better in some people than others * How well REGN22530 works
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 271 (estimated)
- First submitted
- 23 Jun 2026
- Start date
- 8 Sept 2026
- Primary completion date
- 14 Sept 2029
- Lead sponsor
- Regeneron Pharmaceuticals
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT07675824
- EU CT number
- 2026-526004-76-00
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 271
- From 8 Sept 2026 to the primary completion date, 14 Sept 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Congenital or traumatic cataract, or visually significant cataract that is likely to require surgical intervention during the study
- Prior incisional or bleb-forming glaucoma surgery, suprachoroidal procedures, Trabecular Meshwork (TM)-stripping Microinvasive Glaucoma Surgery (MIGS), angle-based implants other than iStent or iridectomy/iridotomy as described in the protocol
- History of Selective Laser Trabeculoplasty (SLT) within 6 months prior to day 1
- History of transscleral (including micropulse) or endoscopic cyclophotocoagulation within 1 year prior to day 1
- Note: Other protocol defined Inclusion/ Exclusion criteria apply
Other illness
- OAG or OHT secondary to pigment dispersion, pseudoexfoliation, trauma, uveitis, neovascularization, a vascular disorder, or steroid use
Other
- Ocular-specific exclusion criteria apply to the Study Eye only, unless otherwise specified.
- Presence of significant corneal scarring or irregularities that could interfere with reliable IOP measurement
Who the study is looking for
- Diagnosis of OHT or POAG of mild to moderate severity as described in the protocol
- Best-Corrected Visual Acuity (BCVA) of ≥35 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (Snellen equivalent of better than or equal to 20/200) in the study eye on day 1
- BCVA of ≥55 EDTRS letters (Snellen equivalent of better than or equal to 20/80) in the non-study eye on day 1
- Phakic or pseudophakic with a posterior chamber intraocular lens that has been implanted ≥3 months prior to Screening Visit 1
- Sufficiently clear ocular media, adequate pupillary dilation and fixation to permit quality posterior segment imaging in the study eye
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Advanced Research Coordinator of this site? Confirm its status | Deerfield Beach | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.