NCT07678489Recruiting
Total en Bloc Urethra Preservation at Robot-assisted Prostatectomy IDEAL Stage 2a
Total en Bloc Urethra Preservation at Robot-assisted Prostatectomy (ToP-RAP): A Prospective IDEAL Stage 2a Study
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
Prospective single-arm IDEAL stage 2a feasibility study of urethra-preserving RARP in localized prostate cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 20 Jun 2026
- Start date
- 30 Jan 2024
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- Sami-Ramzi Leyh-Bannurah
- Diseases
- Prostate cancer
- NCT number
- NCT07678489
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 30 Jan 2024 to the primary completion date, 31 Dec 2030
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- \- Failure to meet any inclusion criterion, or patient declining ToP-RAP (offered standard RARP per EAU guidelines)
Who the study is looking for
- Life expectancy \>=10 years (biological age)
- No prior prostate therapy (laser enucleation, TURP, focal therapy)
- No pelvic/prostate radiotherapy;
- No prior abdominal/rectal surgery;
- No prior (neoadjuvant) androgen-deprivation therapy
- No prior stroke/cerebral ischemia with neurological sequelae;
- No neurological disease (e.g., Parkinson's)
- Transrectal or transperineal bilateral biopsy \>=12 cores (MRI-ultrasound fusion, targeted + systematic)
- PSA \<=15 ng/mL; prostate volume \<=80 mL
- Biopsy ISUP grade 1-3 (= Gleason 3+3 / 3+4 / 4+3)
- No Gleason pattern 5; no intraductal, cribriform or neuroendocrine carcinoma
- mp/bpMRI (mandatory if biopsy Gleason \>=3+4)
- No suspected metastases at staging
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinic Bel Etage Coordinator of this site? Confirm its status | Düsseldorf | Germany | Recruiting |
| Diakonie Klinikum Jung-Stilling Coordinator of this site? Confirm its status | Siegen | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.