NCT07679321Recruiting
The Impact of Anxiety/Depression on the Efficacy of Asthma Control Drugs and the Construction of a Predictive Model for the Risk of Acute Asthma Attacks
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma. It will also analyze the association between anxiety/depression severity and asthma severity. The main questions it aims to answer are: Does anxiety/depression affect the therapeutic effect of asthma controller medications (e.g., asthma control level)? Can a reliable risk prediction model for asthma acute exacerbations be established based on anxiety/depression and other relevant factors? Researchers will conduct a prospective observational study to collect and analyze data from participants, without additional interventions beyond standard clinical care, to explore the above research questions. Participants will: Complete baseline assessments, including demographic information collection, medical history review, lung function tests, anxiety/depression evaluations (via GAD-7 and PHQ-9 scales), and provide biological samples (induced sputum, feces, blood) Undergo follow-up visits at 3, 6, 12, 18, and 24 months after baseline Report asthma symptoms, acute exacerbation events, and cooperate with required clinical checkups during follow-up
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 256 (estimated)
- First submitted
- 1 Jan 2026
- Start date
- 1 Dec 2024
- Primary completion date
- 30 Dec 2027
- Lead sponsor
- Xiangya Hospital of Central South University
- Diseases
- Asthma
- NCT number
- NCT07679321
What you commit to
- Study type: Observational
- Planned participants: 256
- From 1 Dec 2024 to the primary completion date, 30 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of antidepressant or anti-anxiety medications.
Other illness
- History of major lung diseases other than asthma, congestive heart failure, cor pulmonale, or recent cardiac or thoracic surgery.
- Cognitive impairment or inability to complete psychological scale assessments.
- Clinically diagnosed acute or chronic mental disorders, such as bipolar disorder or schizophrenia.
Other
- Incomplete medical records.
- Pregnancy or lactation.
Who the study is looking for
- Diagnosis of asthma according to the Global Initiative for Asthma (GINA) 2024 criteria.
- Male or female patients aged 14 years or older.
- Complete clinical data available.
- Newly diagnosed asthma or stable asthma.
- Receiving asthma controller medication.
Age in the registry: 14 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xiangya Hospital Central South University Coordinator of this site? Confirm its status | Changsha | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.