NCT07679828Recruiting
Polypills Approach for Multiple Cardiovascular Risk Factors
Polypills Approach for Multiple Cardiovascular Risk Factors (PACIF) : a Multicentre, Open-label, Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 16 Sept 2026
Brief summary (registry, in English)
The Polypill Approach for Multiple Cardiovascular Risk Factors (PACIF) trial is a multicenter randomized controlled trial that will test the effectiveness and safety of a fixed-dose combination strategy for the integrated management of hypertension, dyslipidemia, and type 2 diabetes among adults aged 50 to 75 years without prior cardiovascular disease in China. The trial will evaluate whether a fixed-dose combination strategy improves the 10-year cardiovascular disease risk estimated using the PREVENT equations at Phase 1. Participants will be further followed to determine whether the fixed-dose combination strategy reduces major cardiovascular events and improves cognitive outcomes compared with usual care at Phase 2.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 8252 (estimated)
- First submitted
- 21 Jun 2026
- Start date
- 11 Jul 2026
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- China Medical University, China
- Diseases
- High blood pressure
- NCT number
- NCT07679828
What you commit to
- Study type: Interventional
- Planned participants: 8252
- From 11 Jul 2026 to the primary completion date, 31 Dec 2029
- 15 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Clinical diagnosis of dementia or treatment with medications for dementia
Other illness
- Known secondary cause of hypertension
- Type 1 diabetes
- Pancreatic insufficiency or diabetes secondary to pancreatitis
- History of myocardial infarction, stroke, or heart failure
- History of coronary, cerebrovascular, or peripheral arterial revascularization
- History of malignancy
Lab values
- Triglycerides ≥5.65 mmol/L (500 mg/dL)
- Abnormal serum potassium, defined as serum potassium \>5.5 mmol/L or \<3.5 mmol/L
Age
- Life expectancy \<3 years
Other
- Abnormal kidney function, defined as estimated glomerular filtration rate \<30 mL/min/1.73 m² or dialysis
- Abnormal liver function, defined as alanine aminotransferase or aspartate aminotransferase \>3 times the upper limit of normal
- Contraindication to any of the components of the polypill
- Currently living with another PACIF participant
- Pregnancy, currently trying to become pregnant, or of child-bearing potential and not using birth control
- Currently participating in another intervention study
- Any factors judged by the clinic team to be likely to limit adherence to interventions
Who the study is looking for
- Men or women
- Age ≥50 years and \<75 years
- Systolic blood pressure ≥130 mmHg
- LDL-C ≥1.8 mmol/L (70 mg/dL)
- Type 2 diabetes with HbA1c ≥6.5% and \<12%
- Willing to participate and able to sign informed consent
Age in the registry: 50 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (15)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Affiliated Hospital of Chifeng University Coordinator of this site? Confirm its status | Chifeng | China | Recruiting |
| Shandong Provincial Hospital Affiliated to Shandong First Medical University Coordinator of this site? Confirm its status | Jinan | China | Not yet recruiting |
| Central Hospital of Jinzhou Coordinator of this site? Confirm its status | Jinzhou | China | Recruiting |
| Kunshan Hospital of Chinese Medicine Coordinator of this site? Confirm its status | Kunshan | China | Not yet recruiting |
| Panjin Central Hospital Coordinator of this site? Confirm its status | Panjin | China | Not yet recruiting |
| First Hospital of China Medical University Coordinator of this site? Confirm its status | Shenyang | China | Recruiting |
| Shengjing Hospital Of China Medical University Coordinator of this site? Confirm its status | Shenyang | China | Not yet recruiting |
| Suzhou Wujiang District Hospital of Traditional Chinese Medicine Coordinator of this site? Confirm its status | Suzhou | China | Not yet recruiting |
| The Second Affiliated Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Not yet recruiting |
| The Fifth People's Hospital of Wujiang District Coordinator of this site? Confirm its status | Suzhou | China | Not yet recruiting |
| Taixing Second People's Hospital Coordinator of this site? Confirm its status | Taizhou | China | Not yet recruiting |
| Tieling Central Hospital Coordinator of this site? Confirm its status | Tieling | China | Recruiting |
| Tiemei General Hospital of Liaoning Health Industry Group Coordinator of this site? Confirm its status | Tieling | China | Recruiting |
| Tongliao People's Hospital Coordinator of this site? Confirm its status | Tongliao | China | Not yet recruiting |
| The First Affiliated Hospital of Henan University of Chinese Medicine Coordinator of this site? Confirm its status | Zhengzhou | China | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.