NCT07681466Recruiting
Chronology and Sequence of Premonitory Symptoms
Chronology and Sequence of Premonitory Symptoms to Understand How Migraine Attack Starts: the CHRONOpS Study
Source: ClinicalTrials.gov · Last updated 2 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to prospectively investigate the temporal sequence of premonitory symptoms across multiple migraine attacks.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 20 Jun 2026
- Start date
- 17 Mar 2026
- Primary completion date
- Mar 2027
- Lead sponsor
- University of Roma La Sapienza
- Diseases
- Migraine
- NCT number
- NCT07681466
What you commit to
- Study type: Observational
- Planned participants: 500
- From 17 Mar 2026 to the primary completion date, Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of migraine for \< 12 months prior to the inclusion;
Other illness
- History or current diagnosis of secondary headache disorders as defined by ICHD-III;
- History of other neurological comorbidities or major psychiatric disorders;
Other
- Opioid overuse according to the ICHD-III criteria;
- Pregnancy or breastfeeding.
Who the study is looking for
- Diagnosis of episodic (EM) or chronic migraine (CM) or CM with medication overuse headache (MOH) according to ICHD-III criteria;
- Age between 18 and 65 years;
- At least 2 migraine days (MMD) in the month preceding the inclusion;
- Migraine history of at least 12 months prior to inclusion
- Signed written informed consent.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sapienza University of Rome, Polo Pontino, centro cefalee, ICOT Coordinator of this site? Confirm its status | Latina | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.