NCT07682298Recruiting
Assessment of Residual Congestion in Acute Decompensated Heart Failure
Source: ClinicalTrials.gov · Last updated 7 Jul 2026
Brief summary (registry, in English)
DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF). Ultrasound assessment of congestion (VExUS and LUS) will be performed serially during admission: within 48 hours of admission, at the time diuretic therapy is switched from intravenous to oral, and on the day of discharge. The discharge assessment will serve as the primary predictor. Treating physicians will be blinded to all ultrasound findings. Patients will be followed for 90 days by telephone follow-up and chart review for the primary endpoint, with extended chart review at one year for selected secondary endpoints. AIMS: To determine whether combined ultrasound assessment of venous (VExUS) and pulmonary congestion (LUS) at discharge predicts heart failure readmission and all-cause mortality in patients hospitalized with ADHF. HYPOTHESIS: Abnormal VExUS and/or LUS findings at discharge are associated with a higher risk of heart failure readmission and all-cause mortality after 90 days.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 580 (estimated)
- First submitted
- 26 Jun 2026
- Start date
- 15 Feb 2026
- Primary completion date
- 1 Jun 2028
- Lead sponsor
- Aarhus University Hospital
- Diseases
- Heart failure
- NCT number
- NCT07682298
What you commit to
- Study type: Observational
- Planned participants: 580
- From 15 Feb 2026 to the primary completion date, 1 Jun 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Pregnancy
- Moribund
- Solitary kidney
- Inability to provide written consent
Who the study is looking for
- Adults (≥18 years) admitted with ADHF.
- Clinical evidence of congestion during admission, indicated by ≥1 of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiologic/ultrasound evidence of pulmonary congestion.
- Treatment with ≥40 mg i.v. furosemide or equivalent dose loop diuretic during admission.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Aarhus University Hospital - Department of Cardiology Coordinator of this site? Confirm its status | Aarhus | Denmark | Recruiting |
| Copenhagen University Hospital, Amager and Hvidovre Hospital - Department of Cardiology Coordinator of this site? Confirm its status | Copenhagen | Denmark | Not yet recruiting |
| Zealand University Hospital - Department of Cardiology Coordinator of this site? Confirm its status | Roskilde | Denmark | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.