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NCT07682298Recruiting

Assessment of Residual Congestion in Acute Decompensated Heart Failure

Source: ClinicalTrials.gov · Last updated 7 Jul 2026

Brief summary (registry, in English)

DESIGN: A prospective, multicenter, observational cohort study including 580 patients admitted for acute decompensated heart failure (ADHF). Ultrasound assessment of congestion (VExUS and LUS) will be performed serially during admission: within 48 hours of admission, at the time diuretic therapy is switched from intravenous to oral, and on the day of discharge. The discharge assessment will serve as the primary predictor. Treating physicians will be blinded to all ultrasound findings. Patients will be followed for 90 days by telephone follow-up and chart review for the primary endpoint, with extended chart review at one year for selected secondary endpoints. AIMS: To determine whether combined ultrasound assessment of venous (VExUS) and pulmonary congestion (LUS) at discharge predicts heart failure readmission and all-cause mortality in patients hospitalized with ADHF. HYPOTHESIS: Abnormal VExUS and/or LUS findings at discharge are associated with a higher risk of heart failure readmission and all-cause mortality after 90 days.

Status (registry)
Recruiting
Study type
Observational
Enrollment
580 (estimated)
First submitted
26 Jun 2026
Start date
15 Feb 2026
Primary completion date
1 Jun 2028
Lead sponsor
Aarhus University Hospital
NCT number
NCT07682298

What you commit to

  • Study type: Observational
  • Planned participants: 580
  • From 15 Feb 2026 to the primary completion date, 1 Jun 2028
  • 3 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Pregnancy
  • Moribund
  • Solitary kidney
  • Inability to provide written consent

Who the study is looking for

  • Adults (≥18 years) admitted with ADHF.
  • Clinical evidence of congestion during admission, indicated by ≥1 of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiologic/ultrasound evidence of pulmonary congestion.
  • Treatment with ≥40 mg i.v. furosemide or equivalent dose loop diuretic during admission.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (3)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Aarhus University Hospital - Department of Cardiology
Coordinator of this site? Confirm its status
AarhusDenmarkRecruiting
Copenhagen University Hospital, Amager and Hvidovre Hospital - Department of Cardiology
Coordinator of this site? Confirm its status
CopenhagenDenmarkNot yet recruiting
Zealand University Hospital - Department of Cardiology
Coordinator of this site? Confirm its status
RoskildeDenmarkNot yet recruiting

This page is information, not medical advice. Discuss any trial with your doctor.