NCT07684547Not yet recruiting
REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints
REstoration of SYNChronous Cardiac Function Due to Physiologic cArdiac Pacing Modalities With Clinical Endpoints RESYNC-PACE
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
The goal of this observational study is to evaluate the long-term clinical outcomes of physiologic cardiac resynchronization therapy (CRT) using conduction system pacing strategies compared with conventional biventricular CRT in patients with heart failure with reduced ejection fraction (HFrEF) and electrical dyssynchrony. The main questions it aims to answer are: * Does physiologic CRT (including left bundle branch area pacing \[LBBAP\] and LBBAP-optimized CRT) reduce the combined risk of all-cause mortality and heart failure hospitalization compared with conventional biventricular CRT? * Does physiologic CRT improve cardiac function and reverse ventricular remodeling more effectively than conventional CRT? Participants receiving physiologic CRT as part of routine clinical care will undergo standard follow-up evaluations, including electrocardiography, echocardiography, laboratory testing, and device interrogation. Clinical outcomes will be collected prospectively for 24 months and compared with a historical cohort of patients treated with conventional biventricular CRT. The study will assess clinical outcomes, echocardiographic response, electrical resynchronization parameters, and device-related safety in a real-world heart failure population.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 28 Jun 2026
- Start date
- 29 Jun 2026
- Primary completion date
- 29 Jun 2030
- Lead sponsor
- University of Pecs
- Diseases
- Heart failure
- NCT number
- NCT07684547
What you commit to
- Study type: Observational
- Planned participants: 50
- From 29 Jun 2026 to the primary completion date, 29 Jun 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Life expectancy \<12 months due to non-cardiac comorbidities.
- Active systemic infection or infection involving a cardiac implantable electronic device.
- Reversible causes of heart failure expected to improve without CRT.
- Any condition that, in the opinion of the investigators, would make participation inappropriate or interfere with study assessments.
Age
- Age \<18 years and Age 100 \< years
Other
- Pregnancy or breastfeeding.
- Inability or unwillingness to provide informed consent.
- Participation in another interventional clinical trial that may affect study outcomes.
- Inability to comply with follow-up requirements.
- Missing essential baseline or follow-up data (retrospective cohort).
Who the study is looking for
- Age ≥18 years.
- Symptomatic heart failure despite guideline-directed medical therapy.
- Left ventricular ejection fraction (LVEF) ≤40%.
- Indication for cardiac resynchronization therapy according to contemporary ESC guideline recommendations.
- QRS duration ≥150 ms with either:
- Left bundle branch block (LBBB), or Intraventricular conduction delay (IVCD).
- Planned implantation of a CRT system
- Ability to provide written informed consent
- Expected survival greater than 24 months.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Heart Institute , University of Pécs Coordinator of this site? Confirm its status | Pécs | Hungary | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.