NCT07685028Not yet recruiting
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol A
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 250 (estimated)
- First submitted
- 14 May 2026
- Start date
- 6 Oct 2026
- Primary completion date
- 31 Dec 2033
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07685028
What you commit to
- Study type: Interventional
- Planned participants: 250
- From 6 Oct 2026 to the primary completion date, 31 Dec 2033
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Must not have had surgical removal of any portion of the lung, excluding needle or core lung biopsy at the time of enrollment.
- Must not have had a chest CT within 12 months prior to trial enrollment.
Other illness
- Must not have a personal history of lung cancer at the time of enrollment.
- Must not have a personal history of stage IV cancer of any type at the time of enrollment.
Who the study is looking for
- Age: Must meet both the upper and lower age limit criteria.
- Upper age limit: ≤80 years of age
- Lower age limit:
- ≥40 years of age OR
- ≥18 years of age AND ≤10 years of youngest relative's age at time of lung cancer diagnosis (e.g., if a relative was diagnosed at 35 years of age, participant can enroll at ≥25 years of age)
- Positive family history of lung cancer (defined as):
- Has ≥1 first-degree relative, OR
- Has ≥2 second-degree relatives with a diagnosis of non-small cell lung cancer or small cell lung cancer (NB: a first-degree relative = parent, sibling, or child, a second-degree relative = grandparent, blood-related aunt or uncle, grandchild, blood-related niece or nephew, half-sibling)
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.