NCT07688551RecruitingPhase 2/3
Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation
Transcranial Direct Current Stimulation to Treat Aphasia: A Superiority Study
Source: ClinicalTrials.gov · Last updated 21 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- First submitted
- 26 Jun 2026
- Start date
- 14 Jul 2026
- Primary completion date
- Mar 2030
- Lead sponsor
- University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT07688551
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 130
- From 14 Jul 2026 to the primary completion date, Mar 2030
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Seizures during the previous 12-months.
- Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.
- Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.
Other illness
- History of brain surgery except for during the treatment of the acute stroke.
- Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).
- Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.
Other
- Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).
- Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.
Who the study is looking for
- Be willing and able to give informed consent.
- Be willing and able to comply with study requirements.
- Be between 25 and 80 years of age.
- Have used English as the primary language for \> 15 years.
- Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.
- Be greater than 6 months post-stroke.
- Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \< 9).
- Correctly name 140 or fewer items on the PNT.
Age in the registry: 25 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| University of South Carolina Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
| University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.