NCT07690215Not yet recruiting
Study to Assess Effectiveness of Oral Atogepant in Adult Participants For Prevention of Migraine in the United Kingdom
Patient-Reported Outcomes and Healthcare Resource Use in Patients Initiated With Atogepant in a Primary Care Setting for the Prevention of Migraine: An Ambi-spective Real-World Study in the UK (PRACTICE)
Source: ClinicalTrials.gov · Last updated 8 Jul 2026
Brief summary (registry, in English)
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. The study will assess the effectiveness of atogepant for the preventive treatment of migraine in adult patients in the UK. Atogepant is an approved drug for preventive treatment of migraine in adults. Approximately 200 adult participants who are prescribed atogepant by their doctors will be enrolled in this study in the UK. Participants will receive atogepant oral tablets as prescribed by their physician. Participants will be followed for up to week 48. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 2 Jul 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Mar 2028
- Lead sponsor
- AbbVie
- Diseases
- Migraine
- NCT number
- NCT07690215
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Sept 2026 to the primary completion date, 31 Mar 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previously exposed to atogepant as routine therapy before the study period or from clinical trials experience prior to entry.
Other illness
- In the opinion of the prescribing GP or appropriate primary care HCP, the patient has a history or current evidence of any condition that might interfere with the patient's ability to comply with the study requirements.
Other
- Enrolled in any interventional studies that may include investigational compounds for migraine.
- Initiated on atogepant in secondary care and subsequently maintained in primary care.
- Initiated on atogepant in primary care following specialist input via an 'advice and guidance' pathway.
- Contraindications to atogepant administration as per local labelling.
- Pregnant or planning to be pregnant or women of childbearing potential not using contraception.
Who the study is looking for
- Physician-confirmed diagnosis of migraine, classified as either episodic or chronic.
- Have at least 1-year history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders 3rd edition (ICHD-3), 2018.
- Without prior exposure to atogepant who are being prescribed atogepant in primary care for the prophylaxis of migraine with at least 4 migraine days per month.
- Decision to initiate atogepant was made by a prescribing general practitioner (GP) or appropriate primary care health care professional (HCP) within a primary care setting, prior to and independent of any decision to approach the patient regarding participation in the study.
- Willing and able to comply with the requirements of the study, including being able to read and comprehend written English at a level sufficient to understand and complete study patient-reported outcomes (PROs).
- Not on concomitant preventive medication for migraine or have been on a stable preventive medication for migraine for at least 3 months prior to enrolment.
- Access to a suitable device (e.g., laptop, tablet, or smartphone) to complete PRO measures.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.