NCT07691060Completed
Asprosin and Total Antioxidant/Oxidant Status in Diabetes and Periodontal Disease
Evaluation of the Effects of Different Periodontal Statuses on Asprosin and Total Oxidant/Antioxidant Levels in Gingival Crevicular Fluid and Serum of Patients With Type 2 Diabetes: A Cross-sectional Study.
Source: ClinicalTrials.gov · Last updated 8 Jul 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about how different periodontal health status affects the levels of asprosin (a hormone) and total oxidant/antioxidant status in the gingival crevicular fluid and blood serum of individuals with Type 2 diabetes. The main questions it aims to answer are: Do individuals with Type 2 diabetes and periodontal disease have different levels of asprosin and oxidative stress markers compared to diabetic individuals with healthy gingiva ? How do local changes in the gingiva relate to systemic (body-wide) biomarkers in diabetic patients? Participants with Type 2 diabetes will undergo a routine clinical periodontal examination to evaluate their gingival health. During their regular clinic visit, samples of fluid from around their gingiva (gingival crevicular fluid) and routine blood samples (serum) will be collected to measure and compare these biochemical markers
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 67 (actual)
- First submitted
- 12 Jun 2026
- Start date
- 1 Jul 2025
- Primary completion date
- 17 Dec 2025
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- Type 2 diabetes
- NCT number
- NCT07691060
What you commit to
- Study type: Observational
- Participants enrolled: 67
- From 1 Jul 2025 to the primary completion date, 17 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Individuals who had received periodontal treatment within the previous 6 months
- Individuals who had used antibacterial medications within the previous 6 months
Other illness
- Individuals with any disease or medication use that could alter the immune response of the periodontal tissues
- Patients with type 1 diabetes mellitus (T1DM)
Age
- Age younger than 18 years or older than 65 years
Other
- Smokers
- Pregnant women
Who the study is looking for
- Patients with type 2 diabetes mellitus (T2DM) in the gingivitis and periodontitis groups
- Systemically healthy individuals without any systemic disease in the healthy control group
- Age between 18 and 65 years
- Non-smokers
- Individuals with no diseases or medication use that could alter the immune response of the periodontal tissues
- Participants with more than 20 natural teeth
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Health Sciences Türkiye, Gülhane Faculty of Dentistry Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.