NCT07691099Active, not recruiting
Paired Associative Stimulation (PAS) for Stroke Rehabilitation
Comparison of Two Deep TMS Protocols With Paired Associative Stimulation (PAS) for the Treatment of Motor Impairement in Stroke Patients
Source: ClinicalTrials.gov · Last updated 8 Jul 2026
Brief summary (registry, in English)
Paired associative stimulation (PAS) delivered with multi-channel deep transcranial magnetic stimulation (dTMS) may enhance motor recovery in patients with first-ever ischemic stroke. This study evaluates whether dTMS-PAS targeting both primary motor cortices (M1-M1) improves upper-extremity hemiparesis when administered at the early subacute stage (up to three weeks poststroke).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 11 Sept 2025
- Start date
- 10 Nov 2019
- Primary completion date
- 15 Apr 2026
- Lead sponsor
- Soroka University Medical Center
- Diseases
- Stroke
- NCT number
- NCT07691099
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 10 Nov 2019 to the primary completion date, 15 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any previous stroke.
- Prior participation in the present study, or planned participation in another therapeutic trial, prior to the final assessment in this trial.
- Current participation in another study with an investigational drug or device.
- Any intracranial surgery, intraspinal surgery, or serious head trauma (any head injury that required hospitalization) within the past 3 months prior to participation in the current study.
- Intracranial aneurysm, unless surgically or endovascularlytreated more than 3 months prior to participation in the current study.
Other illness
- Minor stroke with non-disabling deficit or rapidly improving neurological symptoms.
- Presence or history of intracranial neoplasm (except small meningiomas) or arteriovenous malformation.
- Seizure at the onset of stroke or a history of epilepsy.
- Cardiac pacemakers, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease.
- Other serious illness, e.g., severe hepatic, cardiac, or renal failure.
- Acute myocardial infarction or complex disease that may confound treatment assessment.
- Cognitive or verbal impairment that prevented understanding of or cooperation with the research study.
- Under the following medical conditions, treatment was stopped, and patients were excluded from the study:
- Acute worsening of \> 4 points on the NIH stroke scale (NIHSS).
- Occurrence of seizures.
- Appearance of a new ventricular arrhythmia, tachycardia, fibrillation etc. or a new life-threatening supraventricular arrhythmia (e.g., rapid atrial fibrillation or supraventricular tachycardia).
- Symptomatic bradycardia - heart rate less than 50 beats per min.
Other
- Women known to be pregnant, lactating or having a positive or indeterminate pregnancy test.
- Life expectancy less than 3 months.
- Acute symptoms of headache nausea and vomiting suggestive of possible sICH.
Who the study is looking for
- The diagnosis of stroke is based on computed tomography (CT) or magnetic resonance imaging (MRI).
- The diagnosis of first acute ischemic stroke in unilateral hemisphere within 3 weeks after onset.
- Clinically evident arm hemiparesis attributable to acute ischemic stroke.
- Age of 18-85 years.
- The ability to sign a informed consent.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Soroke University Medical Center Coordinator of this site? Confirm its status | Beersheba | Israel | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.