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NCT07691255Recruiting

MELanoma Brain Metastasis Treated With CYberknife

Impact of Stereotactic Radiosurgery With Cyberknife In Patients With Brain Melanoma Metastases In The Era Of New Drugs

Source: ClinicalTrials.gov · Last updated 10 Sept 2026

Brief summary (registry, in English)

Melanoma is a type of cancer that can spread to the brain, making the disease harder to treat and worsening both survival and quality of life. In recent years, treatments have improved significantly thanks to advances in surgery, radiotherapy, immunotherapy, and targeted therapy. These new treatments have greatly increased survival rates for patients with metastatic melanoma. This study focuses on stereotactic radiosurgery, a highly precise form of radiotherapy used to treat brain metastases. Researchers want to better understand how this treatment works when combined with immunotherapy or targeted therapy, and whether the timing and sequence of treatments can improve outcomes. Between 2026 and 2028, patients treated at the IEO for melanoma brain metastases will be observed and their clinical data collected. The goal is to improve future treatment strategies and help doctors choose the best therapeutic approach for each patient.

Status (registry)
Recruiting
Study type
Observational
Enrollment
50 (estimated)
First submitted
14 May 2026
Start date
25 Aug 2026
Primary completion date
1 Jan 2030
Lead sponsor
European Institute of Oncology
Diseases
Melanoma
NCT number
NCT07691255

What you commit to

  • Study type: Observational
  • Planned participants: 50
  • From 25 Aug 2026 to the primary completion date, 1 Jan 2030
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous whole-brain radiotherapy or surgical removal of brain metastases

Other

  • Leptomeningeal neoplastic infiltration
  • Patients with histological diagnosis of non-cutaneous melanoma (e.g. uveal melanoma)

Who the study is looking for

  • Age \> 18
  • Written informed consent for treatment and research purposes
  • Melanoma Brain Metastases (MBM) diagnosed with brain MRI/CT
  • MBM treatable with stereotactic radiotherapy
  • Systemic therapy (immunotherapy, target therapy, or both) is allowed, as concurrent or non-concurrent treatment with stereotactic radiotherapy

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
European Institute of Oncology, Milan
Coordinator of this site? Confirm its status
MilanItalyRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.