NCT07692256RecruitingPhase 2
the Clinical Outcome of Empagliflozin in Pediatric Heart Failure Patients
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
the study to investigate the efficacy of empagiflozin in pediatric heart failure
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 4 Jun 2026
- Start date
- 1 Dec 2025
- Primary completion date
- 1 Dec 2026
- Lead sponsor
- Ain Shams University
- Diseases
- Heart failure
- NCT number
- NCT07692256
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 1 Dec 2025 to the primary completion date, 1 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- • Pediatric with chronic kidney failure
- Avoid initiating empagliflozin in patients with concurrent urinary tract infection (UTI).
- patients with eGFR \<60 mL/minute/1.73 m2 will be excluded.
- Patients with contraindication to empagliflozin usage which include
- eGFR \<30 mL/minute/1.73 m2
- Hypersensitivity (eg, angioedema) to empagliflozin
Who the study is looking for
- • Pediatrics (aged 1months-18 years)
- Confirmed HF diagnosis:
- HF will be defined by reduced ventricular systolic function (left ventricular ejection fraction by echocardiography) or impaired ventricular filling (pulmonary capillary wedge pressure \> 18 mmHg measured directly and/or the ratio of early diastolic mitral inflow velocity(E) to early diastolic mitral annular velocity (e')( E/e'\>14 by echocardiography) with clinical features of congestion and/or low cardiac output.
- Class III or IV of ROSS classification or BNP level more than 300 pg/mL
Age in the registry: 1 month to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ain Shams Hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.