NCT07693400Active, not recruitingPhase 2
Topical Chinese Medicine and Exosome Mechanisms for Atopic Dermatitis
Efficacy of Distal Topical Application of a Traditional Chinese Medicinal Ingredient for Atopic Dermatitis and Its Exosome-Mediated Regulatory Mechanisms: Basic and Clinical Studies
Source: ClinicalTrials.gov · Last updated 9 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if menthol works to relieve pruritus in atopic dermatitis. The primary objectives are to evaluate the safety and clinical efficacy of menthol-containing gloves and foot-covers, specifically whether they can improve patient-reported Peak Pruritus Numerical Rating Scale (PP-NRS). Secondary objectives include assessing the Eczema Area Severity Index (EASI), the Dermatology Life Quality Index (DLQI), biochemical examinations (including white blood cell count, hemoglobin, GOT, GPT, creatinine, platelet count, and HbA1c), and exosome analysis. Participants will be asked to: Wear menthol-containing gloves and foot-covers (or shams) for 5 minutes per session, following a schedule of 5 consecutive days of use and 2 days of rest each week, over a total period of 28 days. Attend clinic visits on Days 1, 14, 28, and 42 for evaluations and tests.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 44 (estimated)
- First submitted
- 3 Jul 2026
- Start date
- 29 Apr 2026
- Primary completion date
- 16 Feb 2028
- Lead sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT07693400
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 44
- From 29 Apr 2026 to the primary completion date, 16 Feb 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 9\. Participation in another clinical study within the previous month. The research team may also exclude any participant who is considered unsuitable for the study.
Other illness
- 1\. Allergy to menthol.
- 3\. Secondary infection of skin lesions.
- 4\. Severe peripheral vascular disease, skin lesions, or severe edema at hands/feet.
- 6\. Severe psychiatric conditions.
- 7\. With conditions such as uremia, cirrhosis, congestive heart failure with pulmonary edema, coagulation disorders, epilepsy, alcoholism, drug abuse.
Other
- 2\. Marked fluctuation of AD symptoms.
- 5\. Pregnancy or breastfeeding.
- 8\. Unable to comply with the study protocol or unwilling to provide written consent.
Who the study is looking for
- 1\. Age 12 years or above.
- 2\. Clinical diagnosis of atopic dermatitis based on Hanifin and Rajka criteria.
- 3\. Pruritus severity defined as PP-NRS ≥ 4.
- 4\. Signed the informed consent form that has been approved by the Institutional Review Board.
- 5\. No changes in AD medications within four weeks before enrollment and no change in dosage during the study period.
Age in the registry: 12 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| An Nan Hospital, China Medical University Coordinator of this site? Confirm its status | Tainan | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.