NCT07693868RecruitingPhase 1
A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity
An NNC6022-0004 Single and Multiple Ascending Dose Study Investigating Safety, Tolerability, Pharmacokinetics, Food Effect and Target Engagement in Healthy Adults Including a Single Cohort in Adults Living With Obesity
Source: ClinicalTrials.gov · Last updated 1 Sept 2026
Brief summary (registry, in English)
This study is being done to look at the efficacy single and multiple ascending dose study investigating safety, tolerability, pharmacokinetics, food effect and target engagement in healthy adults including a single cohort in adults living with obesity. Participants will either get NNC6022-0004, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 128 (estimated)
- First submitted
- 3 Jul 2026
- Start date
- 6 Jul 2026
- Primary completion date
- 3 Aug 2027
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT07693868
- EudraCT number
- 2026-525179-26
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 128
- From 6 Jul 2026 to the primary completion date, 3 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of prescription medicinal products or vaccines within 14 days before screening and/or non prescription medicinal products within 7 days before dosing. Exceptions are: Topical medications not reaching systemic circulation; less than once per week of over-the-counter paracetamol, ibuprofen and/or acetylsalicylic acid at their labelled doses for mild pain; vitamins at their labelled doses.
Other illness
- Known or suspected hypersensitivity to study intervention(s) or similar products.
- Any disorder, unwillingness or inability which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol.
Lab values
- Any of the below laboratory safety parameters at screening outside normal range, see designated reference range documents for specific values.
- Alanine Aminotransferase (ALT) \> Upper limit of normal (ULN).
- Alkaline Phosphatase (ALP) \> ULN.
- Aspartate aminotransferase (AST) \> ULN.
- Total Bilirubin (TBL) \> ULN.
- Creatinine \> ULN.
- International normalized ratio (INR) \> ULN.
- Fibrinogen outside normal range of 1.6 - 4.2 grams per liter (g/L).
Other
- hsCRP \> 5.00 mg/L (males) and \> 8.00 mg/L (females)\*.
- applicable for Parts A, B, C and D and for optional Part E: hsCRP \>8.00 mg/L.
Who the study is looking for
- Male, or female of non-childbearing potential.
- For Parts A, B, C and D: Age 18-55 years (both inclusive) at the time of signing the informed consent.
- For optional Part E only: Age 18-65 years (both inclusive) at the time of signing the informed consent.
- -For Parts A, B, C and D: Body mass index (BMI) between 18.5 to 29.9 kilogram per meter square (kg/m\^2) (both inclusive) at screening.
- For optional Part E only: BMI between greater than or equal to (≥) 30.0 to less than or equal to (≤) 45.0 kg/m\^2 at screening, or if BMI is between 27.0 and \<30.0 kg/m\^2, waist to height ratio should be greater than (\>)0.5.
- Body weight: ≥50.0 kilogram (kg) at screening.
- Considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator.
- For optional Part E only: hsCRP ≥2.00 and ≤8.00 milligrams per liter (mg/L) during screening period in 2 separate samples taken ≥4 days apart.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ICON - location Groningen Coordinator of this site? Confirm its status | Groningen | Netherlands | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.