NCT07695233Recruiting
Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease. The PPN is noted to be involved in voluntary movements, locomotion, and muscle tone. This will be assessed by patient-reported outcomes and analyzing the gait. The study will also investigate the effects of the stimulation on the PPN and surrounding connectivity by using magnetic resonance imaging (MRI).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 22 Feb 2026
- Start date
- 17 May 2024
- Primary completion date
- Dec 2027
- Lead sponsor
- Robert Chen
- Diseases
- Parkinson disease
- NCT number
- NCT07695233
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 17 May 2024 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Has intracranial implant(s) or device(s)
- Has a previous surgical intervention to treat the movement disorder such as lesioning or a DBS system in place.
- Is on antipsychotics, marijuana, or other recreational drugs that affect the nervous system
Other illness
- History of stroke or seizure
- Comorbid dementia
- Has an implanted cardiac pacemaker or implantable cardioverter-defibrillator (ICD)
- Major depression/psychiatric disorder that in the opinion of the Investigator will affect patient's understanding of study procedures and willingness to abide by all procedures during the course of the study
- Major musculoskeletal or neuromuscular disease or disorder of the hands, wrists and limbs
- Major systemic illness or infection
Other
- Scored below 22 on the Montreal Cognitive Assessment (MoCA)
- Presence of metal implanted in body that is contraindicated in TMS/MRI
- Pregnancy
Who the study is looking for
- 18-90 years of age
- Confirmed diagnosis of a movement disorder with Freezing of Gait
- Stable dopaminergic medication dose for a minimum of 4 weeks
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Toronto Western Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.