NCT07697274Not yet recruitingEarly phase 1
Hyaluronidase for Sclerodactyly in Systemic Sclerosis Trial
Digital Intradermal Hyaluronidase for Sclerodactyly in Systemic Sclerosis
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
Translational studies have demonstrated reduced hyaluronidase activity in the skin of patients with systemic sclerosis. It is thought this may contribute to the progressive fibrosis seen in this disease. Several studies have demonstrated that exogenous hyaluronidase is very effective at improving systemic sclerosis associated microstomia. Therefore, this study aims to explore hyaluronidase for systemic sclerosis associated sclerodactyly.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 1 Jul 2026
- Start date
- 1 Nov 2026
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Systemic sclerosis (scleroderma)
- NCT number
- NCT07697274
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 10
- From 1 Nov 2026 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent changes in systemic immunomodulatory therapy
Other illness
- Known hypersensitivity to hyaluronidase
- Unstable systemic disease
- Conditions interfering with safe digital injections
Other
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥18 and \<60 years
- Diagnosis of systemic sclerosis
- Presence of sclerodactyly
- Ability to provide informed consent
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.