NCT07697612Not yet recruiting
Durian Consumption in Adults With Type 2 Diabetes Mellitus
Durian Consumption on Human Microbiome and Metabolome in Adults With Type 2 Diabetes Mellitus (DURIOME-T2D)
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
This single-arm clinical trial investigates the effects of daily durian consumption on the gut microbiome, host metabolome, and glucose metrics in adults with type 2 diabetes mellitus (T2DM). Forty adults with T2DM will undergo a pre-durian phase, a durian consumption phase, and a post-durian phase, each lasting 10 to 14 days. Participants will attend five visits at Singapore General Hospital for clinical assessments, continuous glucose monitoring, fasting blood collection, stool sample collection, and dietary and stool record submission. The study aims to determine whether durian consumption alters microbiome and metabolomic profiles and whether it affects glycemic measures in adults with T2DM.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 6 Jul 2026
- Start date
- Aug 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Singapore General Hospital
- Diseases
- Type 2 diabetes
- NCT number
- NCT07697612
What you commit to
- Study type: Interventional
- Planned participants: 40
- From Aug 2026 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous gastrointestinal surgeries, including cholecystectomy, gastrectomy, bariatric surgery, or colectomy.
- Systemic steroid use.
- Weight loss medications, including GLP-1 receptor agonists, orlistat, or phentermine.
Other illness
- Known or suspected intolerance or allergy to durian.
- Inflammatory bowel disease.
- Current hemorrhoids or piles causing rectal bleeding during stool passage.
- Uncontrolled thyroid disease.
- Any factor likely to limit adherence to study protocol, including dementia, substance abuse, poor appointment adherence, or family concerns regarding participation
Lab values
- Known skin reaction to adhesives used in a continuous glucose sensor.
- Uncontrolled diabetes (HbA1c greater than 8.5%).
- Severe hypertriglyceridemia (triglycerides greater than 4.5 mmol/L).
- ALT greater than 3 times upper limit of normal.
- AST greater than 3 times upper limit of normal.
Other
- Smoking.
- Glomerular filtration rate less than 30 mL/min.
- Liver cirrhosis.
- Significant alcohol consumption, defined as more than 20 g/day for women and more than 30 g/day for men.
- Pregnant, breastfeeding, or intending to conceive during the study.
- Insulin use.
- Antibiotic, prebiotic, probiotic, vitamin C, or traditional Chinese medicine use in the last 1 month.
Who the study is looking for
- Age 21 to 70 years.
- Diagnosis of type 2 diabetes mellitus.
- Agrees to consume durian for 2 weeks.
- Body mass index 25 to 40 kg/m².
Age in the registry: 21 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Singapore General Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.