NCT07699354Not yet recruiting
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Gastric Varices
Cyanoacrylate Glue Versus Absorbable Gelatin Sponge for Endoscopic Treatment of Gastric Varices (CoAGS-GV): A Randomized, Patient- and Assessor-Blinded, Non-Inferiority Trial
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Brief summary (registry, in English)
This study compares two endoscopic ultrasound-guided treatments for gastric varices, which are enlarged veins in the stomach that can bleed. Both treatments use small coils placed into the varix. One group will receive coils with cyanoacrylate medical glue, and the other group will receive coils with absorbable gelatin sponge. The purpose of the study is to determine whether absorbable gelatin sponge with coils is not worse than cyanoacrylate glue with coils for closing off gastric varices, and to compare safety outcomes. Participants will be randomly assigned to one of the two treatment groups. Participants and outcome assessors will not know which treatment was used, but the doctor performing the procedure will know. After the procedure, participants will be followed for up to 12 months. Follow-up may include clinical assessments, questionnaires about health and quality of life, CT imaging shortly after the procedure, and repeat endoscopic ultrasound assessments to evaluate whether the gastric varix has been successfully treated.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 64 (estimated)
- First submitted
- 5 Jul 2026
- Start date
- 1 Aug 2026
- Primary completion date
- 1 Nov 2027
- Lead sponsor
- Unity Health Toronto
- Diseases
- High blood pressure
- NCT number
- NCT07699354
What you commit to
- Study type: Interventional
- Planned participants: 64
- From 1 Aug 2026 to the primary completion date, 1 Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No gastric varix present, or gastric varix too small or not amenable to combination therapy.
Other
- Inability or unwillingness to provide informed consent directly or through a substitute decision maker.
- Contraindication to therapeutic EUS or endoscopy.
- Contraindication to any study material used in the assigned treatment arm.
- Contraindication to contrast-enhanced CT, if not clinically manageable.
- Inability to complete planned follow-up.
- Pregnancy.
- Any clinical situation in which the treating endoscopist determines that randomization would be unsafe or inappropriate.
Who the study is looking for
- Adults aged 18 years or older.
- Gastric varices deemed suitable for EUS-guided endoscopic treatment.
- History of suspected gastric variceal bleeding or active gastric variceal bleeding, with treatment intended for secondary prophylaxis.
- Ability to provide informed consent directly or through a substitute decision maker.
- Willingness and ability to undergo clinical follow-up, EUS assessment, and CT imaging.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Michael's Hospital, Unity Health Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.