NCT07700537Recruiting
Efficacy and Neural Mechanisms of Transcranial Direct Current Stimulation Targeting the Supplementary Motor Area for the Treatment of Subacute Post-stroke Aphasia
Study on the Efficacy and Neural Mechanisms of Transcranial Direct Current Stimulation Targeting the Supplementary Motor Area for the Treatment of Subacute Post-stroke Aphasia
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) in patients with post-stroke aphasia (PSA) and to explore its potential neural mechanisms. The study will recruit PSA patients and provide them with 14 tDCS sessions over 7 days, along with speech therapy. Language Behavior Scale scores and resting-state functional MRI scans will be collected before and after the intervention. In addition, a retrospective comparison will be conducted of language function and resting-state fMRI changes in a group of PSA patients who received only speech therapy; these patients did not undergo any physical intervention but received only speech therapy. Changes in Language Behavior Scale scores and functional connectivity (FC) before and after treatment in the speech therapy-only group will be analyzed and compared with those in the tDCS intervention group.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 8 Jul 2026
- Start date
- 30 Jul 2025
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- The First Affiliated Hospital of Anhui Medical University
- Diseases
- Stroke
- NCT number
- NCT07700537
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 30 Jul 2025 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Claustrophobia or implants incompatible with MRI
- History of previous stroke
Other illness
- Time since stroke onset exceeds 12 weeks
- History of psychiatric or neurological disorders
- History of surgery for severe head trauma, brain tumors, or brain abscesses
- Severe articulation disorders
Other
- Inability to cooperate with language scale testing or fMRI scanning
Who the study is looking for
- Patients must be between 18 and 80 years of age
- First stroke in the left hemisphere
- Stroke onset within the past 12 weeks
- Native Chinese speakers who were able to communicate normally prior to onset
- Diagnosed with aphasia using the ABC scale
- Right-handed
- Informed consent obtained from the patient and family members
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| transcranial direct current stimulation (tDCS) Coordinator of this site? Confirm its status | Hefei | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.