NCT07702825Recruiting
Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity
Impact of Weight Loss Interventions on Multiorgan Health, Detected by Quantitative MRI, in Children and Young People With Severe Obesity.
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 1 Jul 2026
- Start date
- 6 Mar 2026
- Primary completion date
- Dec 2027
- Lead sponsor
- Alder Hey Children's NHS Foundation Trust
- Diseases
- Obesity
- NCT number
- NCT07702825
What you commit to
- Study type: Observational
- Planned participants: 30
- From 6 Mar 2026 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any contraindications for MRI- Metal implants/claustrophobia
- Previous use of GLP-1 receptor agonist
Other
- Body weight above upper limit of the scanner (\>250 kilograms)
- Needs general anaesthesia for the MRI scanning
- Refusal to consent or refusal to assent from a competent older adolescent.
Who the study is looking for
- Age 12 to \<18 years at the time of enrolment
- BMI \>99.6th centile or \>2.67 SDS
- Informed consent from parent(s) (or person with parental responsibility) and assent from the child or young person for participants aged less than 16 years (or)
- Informed consent from the participant if aged ≥ 16 years.
Age in the registry: 12 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Alder Hey Children's Hospital Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.