NCT07703215Completed
NPQ Plus Supplementation for Skin Health and Antioxidant Status
Effects of NPQ Plus Supplementation on Skin Health, Antioxidant Status, Fatigue and Self-Perceived Well-being: A Single-Arm Prospective Interventional Study
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
This study evaluated the effects of NPQ Plus supplementation on skin health, antioxidant status, fatigue, and self-perceived well-being in healthy adults with skin concerns. NPQ Plus is a multi-component nutraceutical formulation containing polyphenols (Oligonol®), nicotinamide mononucleotide (NMN; RevAge®), pyrroloquinoline quinone (PQQ; PureQQ®), coenzyme Q10 (CoQ10), and a trace mineral complex (Ioniplex), which are known to possess antioxidant and cellular protective properties. This was a single-arm, open-label, prospective interventional study involving 55 participants. Subjects consumed one sachet of NPQ Plus daily for 12 weeks. Assessments were performed at baseline and at Weeks 4, 8, and 12. Skin health was evaluated using the Patient-Oriented Eczema Measure (POEM), visual analogue scale (VAS), and objective skin biophysical measurements including skin elasticity, hydration, transepidermal water loss (TEWL), pigmentation, inflammation, and sebum secretion. Antioxidant status was assessed by measuring total antioxidant capacity (TAOC), malondialdehyde (MDA), 3-nitrotyrosine (3-NT), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Fatigue symptoms and self-perceived improvements in skin health, sleep quality, and overall well-being were also evaluated.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 55 (actual)
- First submitted
- 8 Jul 2026
- Start date
- 1 Jan 2026
- Primary completion date
- 30 Apr 2026
- Lead sponsor
- N REMEDIER (M) SDN BHD
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT07703215
What you commit to
- Study type: Interventional
- Participants enrolled: 55
- From 1 Jan 2026 to the primary completion date, 30 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Consumption of dietary supplements intended to improve skin health within the previous 3 months.
- Presence of any medical condition or concurrent medication that, in the opinion of the investigator, could interfere with study participation or outcome assessments.
- Participation in another clinical study within the previous 3 months.
Other illness
- Known allergy or hypersensitivity to any ingredient in NPQ Plus.
Other
- Pregnant or breastfeeding women.
- Unable or unwilling to comply with the study protocol.
Who the study is looking for
- Experiencing at least one skin concern (e.g., itchiness, dryness, roughness, flaking, or skin cracking) within the previous 3 months.
- Willing and able to consume one sachet of NPQ Plus daily for 12 weeks.
- Willing to attend all scheduled study visits and assessments.
- Able to understand the study procedures and provide written informed consent.
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSI University Coordinator of this site? Confirm its status | Cheras | Malaysia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.