NCT07703865Completed
Effects of Monday-Thursday Sunnah Fasting on Short-Chain Fatty Acids, GLP-1, Satiety, and Nutritional Status in Obese Males
Effects of Monday-Thursday Sunnah Fasting on Fecal Short-Chain Fatty Acids, Fasting GLP-1, Appetite Regulation, and Body Composition in Obese Adult Males: A Quasi-Experimental Study
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
This quasi-experimental study investigated the effects of 8 weeks of Monday-Thursday Sunnah fasting on fecal short-chain fatty acids (SCFA), fasting total GLP-1, appetite regulation (hunger and satiety area under the curve), dietary intake, and body composition in obese adult males in Indonesia. Monday-Thursday Sunnah fasting is a twice-weekly Islamic religious practice involving complete abstention from food and water (dry fasting) from dawn (approximately 04:30) to sunset (approximately 18:00), approximately 13 hours per day, practiced by millions of Indonesian Muslims. Unlike conventional intermittent fasting protocols, Sunnah fasting is motivated by religious observance, which may enhance adherence. Seventy-four obese adult males were enrolled (intervention n=38, control n=36). The intervention group performed 16 fasting days over 8 weeks without any caloric restriction outside fasting hours. Fecal SCFA were measured by GC-MS; fasting total GLP-1 by ELISA; appetite by Visual Analogue Scale (VAS); dietary intake by 24-hour recall; and body composition by bioelectrical impedance analysis. Primary analyses used linear mixed models (LMM) controlling for baseline differences arising from the sequential allocation design.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 74 (actual)
- First submitted
- 9 Jul 2026
- Start date
- 15 Sept 2025
- Primary completion date
- 11 Dec 2025
- Lead sponsor
- University of Muhammadiyah Jakarta
- Diseases
- Obesity
- NCT number
- NCT07703865
What you commit to
- Study type: Interventional
- Participants enrolled: 74
- From 15 Sept 2025 to the primary completion date, 11 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Regular use of lipid-lowering agents, orlistat, appetite suppressants, or hormonal medications
Other illness
- Diagnosed type 2 diabetes mellitus on oral antidiabetic agents, insulin, or GLP-1 receptor agonists
- Coronary heart disease
- Chronic kidney disease
- Uncontrolled hypertension
Other
- Regular use of probiotics, prebiotics, fiber supplements, omega-3, or herbal supplements
- Excessive alcohol consumption
- Vegetarian diet
- Active smoker
Who the study is looking for
- Male, age ≥ 19 years
- BMI ≥ 25 kg/m² (Asia-Pacific obesity criteria)
- Waist circumference \> 90 cm
- No regular intermittent fasting practice in the prior month
- No antibiotic use in the prior month
- Not currently enrolled in any dietary or weight loss program
- Muslim and willing to perform Monday-Thursday Sunnah fasting
- Residing in DKI Jakarta and surrounding areas (Bogor, Depok, Tangerang)
Age in the registry: 19 years to - · Sex: Male · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta Coordinator of this site? Confirm its status | South Tangerang | Indonesia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.