NCT07704528Active, not recruiting
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Effect of Percutaneous Internal Jugular Vein Catheterization on Intracranial Pressure in Patients With Acute Brain Injury
Source: ClinicalTrials.gov · Last updated 15 Jul 2026
Brief summary (registry, in English)
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain. Patients with ABI often need a central venous catheter (CVC) - a small, flexible tube placed into a large neck vein - to receive medications, fluids, and to monitor their circulation. However, placing this catheter might temporarily affect brain pressure, either because of the patient's head position during the procedure or the procedure itself. The effect size and duration are not yet known. The purpose of this observational study is to understand how placing a CVC in the neck (internal jugular vein) affects brain pressure in patients with acute brain injury. The study will closely monitor changes in brain pressure, blood flow, and oxygen levels in the brain during and immediately after the procedure. The study will also examine whether the brain's ability to regulate its own blood flow (called cerebral autoregulation) influences these changes. This prospective, observational study will enroll approximately 100-120 adult patients with ABI who are in the Intensive Care Unit (ICU) and need a CVC as part of their regular medical care. The study will be conducted in two large hospitals in China. There is no experimental treatment or intervention; only observation and data recording during the standard medical procedure will be performed. The main goal is to measure how brain pressure changes during CVC insertion. The study will also look at how long any changes last and whether the brain's blood flow regulation is affected. The results will help doctors better understand the risks of this common procedure and guide safer management of ABI patients in the ICU.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 15 Jun 2026
- Start date
- 1 Mar 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Beijing Tiantan Hospital
- Diseases
- High blood pressure
- NCT number
- NCT07704528
What you commit to
- Study type: Observational
- Planned participants: 120
- From 1 Mar 2026 to the primary completion date, 31 Dec 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- Any contraindication to internal jugular catheterization exists (severe coagulopathy with INR \> 1.5 or platelets \< 50×10⁹/L; neck infection, tumor, prior surgery or anatomical abnormality on either side; or bilateral jugular veins already catheterized)
Other
- Informed consent not obtained
- Intracranial pressure (ICP) \> 22 mmHg within the past 48 hours
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥ 18 years
- Admitted to the ICU with acute brain injury (including traumatic brain injury, spontaneous intracerebral hemorrhage, large hemispheric infarction, or aneurysmal subarachnoid hemorrhage) and ICU stay ≥ 24 hours
- Invasive intracranial pressure (ICP) monitoring in place as part of clinical care
- Scheduled to undergo percutaneous internal jugular vein catheterization (central venous catheter) as determined by the treating physician
- Written informed consent obtained from the patient or legally authorized representative
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Tiantan Hospital,Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The Second People's Hospital of Guiyang Coordinator of this site? Confirm its status | Guiyang | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.