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NCT07711327Not yet recruiting

Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy

Source: ClinicalTrials.gov · Last updated 17 Jul 2026

Brief summary (registry, in English)

This study looks at how often atrial fibrillation (AF), an irregular heart rhythm, occurs in people with certain blood cancers who are starting a type of cancer medicine called a Bruton's tyrosine kinase inhibitor (BTKI). Researchers will follow 400 people starting BTKI therapy and compare them to 100 people with similar blood cancers who are not taking a BTKI. Participants will wear a smartwatch and, later, a heart monitor patch to check for AF and other irregular heart rhythms over 12 months. The study will also look at whether AF affects cancer treatment, such as needing to pause, lower the dose, or stop the BTKI, and whether it leads to other health problems such as bleeding, stroke, or heart-related hospital visits.

Status (registry)
Not yet recruiting
Study type
Observational
Enrollment
500 (estimated)
First submitted
14 Jul 2026
Start date
Aug 2026
Primary completion date
Aug 2031
Lead sponsor
Tina Baykaner
NCT number
NCT07711327

What you commit to

  • Study type: Observational
  • Planned participants: 500
  • From Aug 2026 to the primary completion date, Aug 2031
  • 3 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior exposure to BTKI therapy

Other illness

  • History of persistent atrial fibrillation

Who the study is looking for

  • Age greater than 18 years
  • Diagnosis of chronic lymphocytic leukemia (CLL), Waldenstrom macroglobulinemia (WM), mantle cell lymphoma (MCL), or marginal zone lymphoma (MZL)
  • New initiation of Bruton's tyrosine kinase inhibitor (BTKI) therapy or non-BTKI therapy (eg, venetoclax based) for management of hematologic malignancy

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (3)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
City of Hope
Coordinator of this site? Confirm its status
DuarteUnited StatesUnknown status
UC San Diego Health
Coordinator of this site? Confirm its status
San DiegoUnited StatesUnknown status
Stanford Health Care
Coordinator of this site? Confirm its status
StanfordUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.