NCT07711834Completed
Exercise and PPARGC1A rs8192678 in Older Adults With Type 2 Diabetes and Cognitive Impairment
Association Between PPARGC1A rs8192678 Polymorphism and the Effects of a 12-Week Combined Aerobic and Resistance Exercise Intervention in Older Adults With Type 2 Diabetes Mellitus and Cognitive Impairment
Source: ClinicalTrials.gov · Last updated 17 Jul 2026
Brief summary (registry, in English)
This completed single-arm interventional study evaluated changes in metabolic control, cognitive function, and health-related physical fitness following a 12-week combined aerobic and resistance exercise program in older adults with type 2 diabetes mellitus and cognitive impairment. The study also explored whether the magnitude of response to exercise differed according to PPARGC1A rs8192678 genotype. A total of 75 participants were genotyped, and 45 participants were included in a balanced genotype-stratified cohort, consisting of 15 participants with the CC genotype, 15 with the CT genotype, and 15 with the TT genotype. All participants received the same exercise intervention and were assessed at baseline and at Week 12.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 45 (actual)
- First submitted
- 7 Jul 2026
- Start date
- 1 Mar 2025
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- Harbin Sport University
- Diseases
- Type 2 diabetes
- NCT number
- NCT07711834
What you commit to
- Study type: Interventional
- Participants enrolled: 45
- From 1 Mar 2025 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Diabetic ketoacidosis within the previous three months.
Other illness
- Visual or hearing impairment or other conditions affecting cognitive assessment.
- Fracture, limb disability, or other motor disorders affecting exercise participation.
- History of psychiatric disorders.
- History of stroke, brain tumor, hypothyroidism, or other diseases that may affect cognitive function.
- Poor compliance or failure to follow the prescribed diet or exercise requirements.
Who the study is looking for
- Diagnosed with type 2 diabetes mellitus.
- No regular exercise training during the previous six months.
- Aged 65 to 79 years.
- Self-reported memory decline and Montreal Cognitive Assessment score \<26.
- Stable antidiabetic medication use and stable dietary control.
- Participant or family member provided informed consent.
Age in the registry: 65 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Harbin Sport University Coordinator of this site? Confirm its status | Harbin | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.